Evidence map›Paper›PMID 31519745›Full record

ArticleG3 (Bethesda, Md.)2019

Multiple Changes Underlie Allelic Divergence of

Xueying C Li, Justin C Fay

Open access · goldAbstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Deconstruction ofbioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. eLife · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Xueying C LiMolecular Genetics and Genomics Program, Division of Biology and Biomedical Sciences, xueying.li@embl.de.ORCID 0000-0002-1100-4694
Justin C FayDepartment of Genetics, and.
Institut thématique Génétique, génomique et bioinformatique · FRUniversity of Rochester · US

Funding

Genetic basis and evolution of thermotolerance in the Saccharomyces yeast speciesR01GM080669 · NIGMS · WASHINGTON UNIVERSITY · PI FAY, JUSTIN C · 2007 to 2025
$5.3M
NIGMS NIH HHS R01 GM080669
6 · The paper itself

Abstract

Under the model of micromutationism, phenotypic divergence between species is caused by accumulation of many small-effect changes. While mapping the causal changes to single nucleotide resolution could be difficult for diverged species, genetic dissection via chimeric constructs allows us to evaluate whether a large-effect gene is composed of many small-effect nucleotide changes. In a previously described non-complementation screen, we found an allele difference of

Indexed as

AllelesCopperDNA-Binding ProteinsDrug ResistanceEvolution, MolecularNucleotidesSaccharomycesSaccharomyces cerevisiae ProteinsTranscription FactorsCopperCUP2 protein, S cerevisiaeDNA-Binding ProteinsNucleotidesSaccharomyces cerevisiae ProteinsTranscription Factorschimerascis-regulatory evolutioncopper resistanceCUP2Saccharomyces

Identifiers

PMID31519745
PMCPMC6829129
OpenAlexW2972664637

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.