Evidence map›Paper›PMID 31519744›Full record

ArticleG3 (Bethesda, Md.)2019

Activity-Dependent Regulation of the Proapoptotic BH3-Only Gene

Jesse Cohn, Vivek Dwivedi, Giulio Valperga, Nicole Zarate, Mario de Bono, H Robert Horvitz, Jonathan T Pierce

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in G3 (Bethesda, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Nonapoptotic role of EGL-1 in exopher production and neuronal health inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Non-apoptotic role of EGL-1 in exopher production and neuronal health inbioRxiv : the preprint server for biology · 2024
    Article
  3. Review
  4. Non-Canonical Roles of Apoptotic Caspases in the Nervous System.Frontiers in cell and developmental biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jesse CohnDepartment of Neuroscience; Center for Brain, Behavior and Evolution; Center for Learning and Memory; Waggoner Center for Alcohol and Addiction Research; Institute of Cell and Molecular Biology, University of Texas at Austin, Austin, Texas.
Vivek DwivediHoward Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, and.
Giulio ValpergaDivision of Cell Biology, Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom.
Nicole ZarateDepartment of Neuroscience; Center for Brain, Behavior and Evolution; Center for Learning and Memory; Waggoner Center for Alcohol and Addiction Research; Institute of Cell and Molecular Biology, University of Texas at Austin, Austin, Texas.
Mario de BonoDivision of Cell Biology, Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom.
H Robert HorvitzHoward Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, and.
Jonathan T PierceDepartment of Neuroscience; Center for Brain, Behavior and Evolution; Center for Learning and Memory; Waggoner Center for Alcohol and Addiction Research; Institute of Cell and Molecular Biology, University of Texas at Austin, Austin, Texas, jonps@austin.utexas.edu.ORCID 0000-0002-9619-4713

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
High-speed opto-fluidics to screen entire nervous system in aging and diseaseR01AG041135 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI BEN-YAKAR, ADELA, PIERCE, JONATHAN THOMAS · 2011 to 2015
$2.8M
Synergistic patterned neurodegeneration by APP and APOE4RF1AG057355 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI PIERCE, JONATHAN THOMAS · 2017 to 2017
$1.9M
Medical Research Council MC_U105178786NIA NIH HHS R01 AG041135NIA NIH HHS RF1 AG057355NIH HHS P40 OD010440
6 · The paper itself

Abstract

The BH3-only family of proteins is key for initiating apoptosis in a variety of contexts, and may also contribute to non-apoptotic cellular processes. Historically, the nematode

Indexed as

AnimalsBiological AssayCaenorhabditis elegansCaenorhabditis elegans ProteinsDendritesLongevityPseudomonas aeruginosaRepressor ProteinsSensory Receptor CellsCaenorhabditis elegans ProteinsEGL-1 protein, C elegansRepressor ProteinsapoptosisBH3-onlyC. elegansegl-1URX

Identifiers

PMID31519744
PMCPMC6829140

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.