ArticleeNeuro
Differential Effects of Dorsal and Ventral Medial Prefrontal Cortex Inactivation during Natural Reward Seeking, Extinction, and Cue-Induced Reinstatement.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Voxel-wise Functional Connectivity of the Default Mode Network in Epilepsies: A Systematic Review and Meta-Analysis.Current neuropharmacology · 2022Pooled it
- Aberrant Medial Prefrontal Cortex Activity and Flexible Behavior in the TgF344-AD Rat Model of Alzheimer's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Biomolecular correlates of incubated sucrose-seeking within ventromedial prefrontal cortex are sex- and subregion-selective.Pharmacology, biochemistry, and behavior · 2025Article
- Drug-Related Engrams and Their Role in the Persistence and Recurrence of Drug-Related Behaviors.Hippocampus · 2025Review
- Cortico-subcortical networks that determine behavioral memory renewal are redefined by noradrenergic neuromodulation.Scientific reports · 2025Article
- Differential reductions in alcohol consumption and cue-induced alcohol-seeking behavior following mGlu5 receptor inhibition in the prelimbic vs. infralimbic subregions of the rat prefrontal cortex.Pharmacology, biochemistry, and behavior · 2025Article
- Divergent reward cue representations in prefrontal cortex underlie differences in reward motivation between adolescents and adults.bioRxiv : the preprint server for biology · 2024Article
- The projection from dorsal medial prefrontal cortex to basolateral amygdala promotes behaviors of negative emotion in rats.Frontiers in neuroscience · 2024Article
- Estrogens rapidly shape synaptic and intrinsic properties to regulate the temporal precision of songbird auditory neurons.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Infralimbic Projections to the Nucleus Accumbens Shell and Amygdala Regulate the Encoding of Cocaine Extinction Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Selective Modulation of Hippocampal Theta Oscillations in Response to Morphine versus Natural Reward.Brain sciences · 2023Article
- Maternal neglect alters reward-anticipatory behavior, social status stability, and reward circuit activation in adult male rats.Frontiers in neuroscience · 2023Article
- Selective ablation of VIP interneurons in the rodent prefrontal cortex results in increased impulsivity.PloS one · 2023Article
- Alcohol and cannabinoid binges and daily exposure to nicotine in adolescent/young adult rats induce sex-dependent long-term appetitive instrumental learning impairment.Frontiers in behavioral neuroscience · 2023Article
- Cortico-Striatal Control over Adaptive Goal-Directed Responding Elicited by Cues Signaling Sucrose Reward or Punishment.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Comparison of prefrontal cortex sucrose seeking ensembles engaged in multiple seeking sessions: Context is key.Journal of neuroscience research · 2022Article
- The rodent medial prefrontal cortex and associated circuits in orchestrating adaptive behavior under variable demands.Neuroscience and biobehavioral reviews · 2022Review
- Where Actions Meet Outcomes: Medial Prefrontal Cortex, Central Thalamus, and the Basal Ganglia.Frontiers in behavioral neuroscience · 2022Review
- Chemogenetic inhibition of corticostriatal circuits reduces cued reinstatement of methamphetamine seeking.Addiction biology · 2022Article
- A Subset of Nucleus Accumbens Neurons Receiving Dense and Functional Prelimbic Cortical Input Are Required for Cocaine Seeking.Frontiers in cellular neuroscience · 2022Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
Rodent dorsal medial prefrontal cortex (mPFC), typically prelimbic cortex, is often described as promoting actions such as reward seeking, whereas ventral mPFC, typically infralimbic cortex, is thought to promote response inhibition. However, both dorsal and ventral mPFC are necessary for both expression and suppression of different behaviors, and each region may contribute to different functions depending on the specifics of the behavior tested. To better understand the roles of dorsal and ventral mPFC in motivated behavior we pharmacologically inactivated each area during operant fixed ratio 1 (FR1) seeking for a natural reward (sucrose), extinction, cue-induced reinstatement, and progressive ratio (PR) sucrose seeking in male Long-Evans rats. Bilateral inactivation of dorsal mPFC, but not ventral mPFC increased reward seeking during FR1. Inactivation of both dorsal and ventral mPFC decreased seeking during extinction. Bilateral inactivation of ventral mPFC, but not dorsal mPFC decreased reward seeking during cue-induced reinstatement. No effect of inactivation was found during PR. Our data contrast sharply with observations seen during drug seeking and fear conditioning, indicating that previously established roles of dorsal mPFC = going versus ventral mPFC = stopping are not applicable to all motivated behaviors and/or outcomes. Our results indicate that dichotomous functions of dorsal versus ventral mPFC, if they exist, may align better with other models, or may require the development of a new framework in which these multifaceted brain areas play different roles in action control depending on the behavioral context in which they are engaged.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.