Evidence map›Paper›PMID 31519145›Full record

ArticleJournal of neurodevelopmental disorders2019

Within-task variability on standardized language tests predicts autism spectrum disorder: a pilot study of the Response Dispersion Index.

Abby E Hare-Harris, Marissa W Mitchel, Scott M Myers, Aaron D Mitchel, Brian R King, Brittany G Ruocco, Christa Lese Martin, Judy F Flax, Linda M Brzustowicz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurodevelopmental disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Abby E Hare-HarrisDepartment of Biological and Allied Health Sciences, Hartline Science Center, Bloomsburg University, 400 East Second St, Bloomsburg, PA, 17815, USA. ahare@bloomu.edu.ORCID 0000-0001-8114-0379
Marissa W MitchelAutism & Developmental Medicine Institute, Geisinger Health System, 120 Hamm Drive, Suite 2A, Lewisburg, PA, 17837, USA.
Scott M MyersAutism & Developmental Medicine Institute, Geisinger Health System, 120 Hamm Drive, Suite 2A, Lewisburg, PA, 17837, USA.
Aaron D MitchelPsychology Department, O'Leary Center, Bucknell University, Lewisburg, PA, 17837, USA.
Brian R KingComputer Science Department, Breakiron Building, Bucknell University, Lewisburg, PA, 17837, USA.
Brittany G RuoccoGenetics Department, Life Sciences Building, Rutgers University, 145 Bevier Road, Piscataway, NJ, 08854, USA.
Christa Lese MartinAutism & Developmental Medicine Institute, Geisinger Health System, 120 Hamm Drive, Suite 2A, Lewisburg, PA, 17837, USA.
Judy F FlaxGenetics Department, Life Sciences Building, Rutgers University, 145 Bevier Road, Piscataway, NJ, 08854, USA.
Linda M BrzustowiczGenetics Department, Life Sciences Building, Rutgers University, 145 Bevier Road, Piscataway, NJ, 08854, USA.
Autism & Developmental Medicine Institute · USRutgers, The State University of New Jersey · USBucknell University · USBloomsburg University · US

Funding

GENE DOSAGE IMBALANCE IN NEURODEVELOPMENTAL DISORDERSR01MH074090 · NIMH · GEISINGER CLINIC · PI David H. Ledbetter, CHRISTA LESE MARTIN · 2005 to 2026
$13.5M
Genetic Components of Autism Spectrum DisordersR01MH070366 · NIMH · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI BRZUSTOWICZ, LINDA M · 2003 to 2007
$3.6M
Gender differences in quantitative measures of autonomic function and clinical features of the autism phenotypeR01MH107431 · NIMH · GEISINGER CLINIC · PI MARTIN, CHRISTA LESE · 2015 to 2019
$3.4M
Behavioral and Genetic Biomarker Development for Autism and Related DisordersRC1MH088288 · NIMH · RUTGERS, THE STATE UNIV OF N.J. · PI BRZUSTOWICZ, LINDA M · 2009 to 2010
$994k
NIMH NIH HHS R01 MH070366NIMH NIH HHS R01 MH074090NIMH NIH HHS R01MH074090NIMH NIH HHS R01 MH107431NIMH NIH HHS R01MH70366NIMH NIH HHS RC1 MH088288NIMH NIH HHS RC1MH088288
6 · The paper itself

Abstract

backgroundQualitatively atypical language development characterized by non-sequential skill acquisition within a developmental domain, which has been called developmental deviance or difference, is a common characteristic of autism spectrum disorder (ASD). We developed the Response Dispersion Index (RDI), a measure of this phenomenon based on intra-subtest scatter of item responses on standardized psychometric assessments, to assess the within-task variability among individuals with language impairment (LI) and/or ASD.

methodsStandard clinical assessments of language were administered to 502 individuals from the New Jersey Language and Autism Genetics Study (NJLAGS) cohort. Participants were divided into four diagnostic groups: unaffected, ASD-only, LI-only, and ASD + LI. For each language measure, RDI was defined as the product of the total number of test items and the sum of the weight (based on item difficulty) of test items missed. Group differences in RDI were assessed, and the relationship between RDI and ASD diagnosis among individuals with LI was investigated for each language assessment.

resultsAlthough standard scores were unable to distinguish the LI-only and ASD/ASD + LI groups, the ASD/ASD + LI groups had higher RDI scores compared to LI-only group across all measures of expressive, pragmatic, and metalinguistic language. RDI was positively correlated with quantitative ASD traits across all subgroups and was an effective predictor of ASD diagnosis among individuals with LI.

conclusionsThe RDI is an effective quantitative metric of developmental deviance/difference that correlates with ASD traits, supporting previous associations between ASD and non-sequential skill acquisition. The RDI can be adapted to other clinical measures to investigate the degree of difference that is not captured by standard performance summary scores.

Indexed as

Language DevelopmentLanguage TestsPsychometricsTask Performance and AnalysisAdolescentAdultAutism Spectrum DisorderCohort StudiesFemaleHumansLanguage DisordersMaleMiddle AgedPilot ProjectsRetrospective StudiesYoung AdultAutism spectrum disorderDevelopmental differenceIntra-subtest scatterLanguage impairment

Identifiers

PMID31519145
PMCPMC6744656
OpenAlexW2972945566

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.