Evidence map›Paper›PMID 31518900›Full record

ArticleiScience2019

Pollen-derived RNAs Are Found in the Human Circulation.

Milka Koupenova, Eric Mick, Heather A Corkrey, Anupama Singh, Selim E Tanriverdi, Olga Vitseva, Daniel Levy, Allison M Keeler, Marzieh Ezzaty Mirhashemi, Mai K ElMallah and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Megakaryocyte and Platelet Transcriptomics for Discoveries in Human Health and Disease.Arteriosclerosis, thrombosis, and vascular biology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Milka KoupenovaDepartment of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, 368 Plantation St., AS7-1051, Worcester, MA 01605, USA. Electronic address: milka.koupenova@umassmed.edu.
Eric MickDepartment of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Heather A CorkreyDepartment of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, 368 Plantation St., AS7-1051, Worcester, MA 01605, USA.
Anupama SinghDepartment of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, 368 Plantation St., AS7-1051, Worcester, MA 01605, USA.
Selim E TanriverdiDepartment of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, 368 Plantation St., AS7-1051, Worcester, MA 01605, USA.
Olga VitsevaDepartment of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, 368 Plantation St., AS7-1051, Worcester, MA 01605, USA.
Daniel LevyThe Framingham Heart Study, Framingham, MA, USA; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Allison M KeelerDepartment of Pediatrics, Division of Pulmonary Medicine and Horae Gene Therapy Center, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Marzieh Ezzaty MirhashemiDepartment of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, 368 Plantation St., AS7-1051, Worcester, MA 01605, USA.
Mai K ElMallahDepartment of Pediatrics, Division of Pulmonary Medicine and Horae Gene Therapy Center, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Mark GersteinProgram in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA; Department of Computer Science, Yale University, New Haven, CT 06520, USA.
Joel RozowskyProgram in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.
Kahraman TanriverdiDepartment of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, 368 Plantation St., AS7-1051, Worcester, MA 01605, USA.
Jane E FreedmanDepartment of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, 368 Plantation St., AS7-1051, Worcester, MA 01605, USA. Electronic address: jane.freedman@umassmed.edu.
University of Massachusetts Chan Medical School · USYale University · USFramingham Heart Study · US

Funding

Racial and Ethnic Diversity in Human Extracellular RNAU01HL126495 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FREEDMAN, JANE E, GERSTEIN, MARK BENDER · 2014 to 2018
$3.4M
Extracellular RNAs: Biomarkers for Cardiovascular Risk and DiseaseUH3TR000921 · NCATS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FREEDMAN, JANE E · 2015 to 2017
$3.1M
THE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–
NCATS NIH HHS UH3 TR000921NHLBI NIH HHS N01 HC025195NHLBI NIH HHS U01 HL126495
6 · The paper itself

Abstract

The presence of nonhuman RNAs in man has been questioned and it is unclear if food-derived miRNAs cross into the circulation. In a large population study, we found nonhuman miRNAs in plasma by RNA sequencing and validated a small number of pine-pollen miRNAs by RT-qPCR in 2,776 people. The presence of these pine-pollen miRNAs associated with hay fever and not with overt cardiovascular or pulmonary disease. Using in vivo and in vitro models, we found that transmission of pollen-miRNAs into the circulation occurs via pulmonary transfer and this transfer was mediated by platelet-pulmonary vascular cell interactions and platelet pollen-DNA uptake. These data demonstrate that pollen-derived plant miRNAs can be horizontally transferred into the circulation via the pulmonary system in humans. Although these data suggest mechanistic plausibility for pulmonary-mediated plant-derived miRNA transfer into the human circulation, our large observational cohort data do not implicate major disease or risk factor association.

Indexed as

Biological SciencesMolecular BiologyOmicsTranscriptomics

Identifiers

PMID31518900
PMCPMC6742912
OpenAlexW2969453805

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.