Evidence map›Paper›PMID 31518848›Full record

ArticleComprehensive psychiatry2019

Trichotillomania comorbidity in a sample enriched for familial obsessive-compulsive disorder.

Ted Avi Gerstenblith, Ashley Jaramillo-Huff, Tuua Ruutiainen, Paul S Nestadt, Jack F Samuels, Marco A Grados, Bernadette A Cullen, Mark A Riddle, Kung-Yee Liang, Benjamin D Greenberg and 7 more

Open access · goldAbstract read
In one paragraph

Article in Comprehensive psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
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  4. Untangling rapunzel syndrome: A unique presentation of gastric trichobezoar.International journal of surgery case reports · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 9 institutions in 2 countries.

Ted Avi GerstenblithJohns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, United States of America.
Ashley Jaramillo-HuffUniversity of New Mexico School of Medicine, Department of Obstetrics and Gynecology, United States of America.
Tuua RuutiainenUniversity of Pennsylvania Perelman School of Medicine, Department of Psychiatry, United States of America.
Paul S NestadtJohns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, United States of America.
Jack F SamuelsJohns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, United States of America.
Marco A GradosJohns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, United States of America.
Bernadette A CullenJohns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, United States of America.
Mark A RiddleJohns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, United States of America.
Kung-Yee LiangNational Yang-Ming University, Taiwan.
Benjamin D GreenbergBrown Medical School, Department of Psychiatry and Human Behavior, United States of America.
Steven A RasmussenBrown Medical School, Department of Psychiatry and Human Behavior, United States of America.
Scott L RauchHarvard Medical School, Department of Psychiatry, United States of America.
James T McCrackenUniversity of California, Los Angeles School of Medicine, Department of Psychiatry and Biobehavioral Sciences, United States of America.
John PiacentiniUniversity of California, Los Angeles School of Medicine, Department of Psychiatry and Biobehavioral Sciences, United States of America.
James A KnowlesSUNY Downstate Medical Center College of Medicine, Department of Cell Biology, United States of America.
Gerald NestadtJohns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, United States of America.
O Joseph BienvenuJohns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, United States of America. Electronic address: obienve1@jhmi.edu.
Johns Hopkins Medicine · USJohns Hopkins University · USJohn Brown University · USUniversity of California, Los Angeles · USHarvard University · USNational Yang Ming University Hospital · TWSUNY Downstate Health Sciences University · USUniversity of New Mexico · USUniversity of Pennsylvania · US

Funding

ZINC AND CA EDTA THERAPY OF PLUMBISMM01RR000052 · NCRR · JOHNS HOPKINS UNIVERSITY · PI BELCHER, HAROLYN MILLICENT EDITH · 1985 to 2007
$37.3M
FAMILY STUDY OF OBSESSIVE COMPULSIVE DISORDERR01MH050214 · NIMH · JOHNS HOPKINS UNIVERSITY · PI NESTADT, GERALD · 1995 to 2005
$6.6M
OCD Collaborative Genetics Association StudyR01MH071507 · NIMH · JOHNS HOPKINS UNIVERSITY · PI NESTADT, GERALD · 2007 to 2010
$6.5M
Formation of Neuronal Cholinergic SynapsesR01NS042609 · NINDS · DUKE UNIVERSITY · PI FENG, GUOPING · 2002 to 2006
$1.7M
Phenomenology of Obsessive Compulsive Personality DisorderK23MH080221 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI PINTO, ANTHONY · 2008 to 2012
$925k
LINKAGE &ASSOCIATION IN OBSESSIVE-COMPULSIVE DISORDERK23MH066284 · NIMH · JOHNS HOPKINS UNIVERSITY · PI GRADOS, MARCO A · 2002 to 2006
$887k
Personality, anxiety, and depression in community adultsK23MH064543 · NIMH · JOHNS HOPKINS UNIVERSITY · PI BIENVENU, O. JOSEPH · 2003 to 2007
$839k
NCRR NIH HHS M01 RR000052NIMH NIH HHS K23 MH064543NIMH NIH HHS K23 MH066284NIMH NIH HHS K23 MH080221NIMH NIH HHS R01 MH050214NIMH NIH HHS R01 MH071507NINDS NIH HHS R01 NS042609
6 · The paper itself

Abstract

backgroundThis study addresses the strength of associations between trichotillomania (TTM) and other DSM-IV Axis I conditions in a large sample (n = 2606) enriched for familial obsessive-compulsive disorder (OCD), to inform TTM classification.

methodsWe identified participants with TTM in the Johns Hopkins OCD Family Study (153 families) and the OCD Collaborative Genetics Study, a six-site genetic linkage study of OCD (487 families). We used logistic regression (with generalized estimating equations) to assess the strength of associations between TTM and other DSM-IV disorders.

resultsTTM had excess comorbidity with a number of conditions from different DSM-IV chapters, including tic disorders, alcohol dependence, mood disorders, anxiety disorders, impulse-control disorders, and bulimia nervosa. However, association strengths (odds ratios) were highest for kleptomania (6.6), pyromania (5.8), OCD (5.6), skin picking disorder (4.4), bulimia nervosa (3.5), and pathological nail biting (3.4).

conclusionsTTM is comorbid with a number of psychiatric conditions besides OCD, and it is strongly associated with other conditions involving impaired impulse control. Though DSM-5 includes TTM as an OCD-related disorder, its comorbidity pattern also emphasizes the impulsive, appetitive aspects of this condition that may be relevant to classification.

Indexed as

AdultComorbidityDiagnostic and Statistical Manual of Mental DisordersDisruptive, Impulse Control, and Conduct DisordersFemaleGenetic LinkageHumansMaleMiddle AgedObsessive-Compulsive DisorderTrichotillomaniaYoung AdultclassificationComorbidityImpulse-control disorderObsessive-compulsive disorderTrichotillomania

Identifiers

PMID31518848
PMCPMC6980465
OpenAlexW2970660999

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.