ArticleAngewandte Chemie (International ed. in English)2019
Volatile Organic Compound Based Probe for Induced Volatolomics of Cancers.
Article in Angewandte Chemie (International ed. in English), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Volatile organic compounds in exhaled human breath for the diagnosis of malignant pleural mesothelioma: a meta-analysis.Frontiers in oncology · 2025Pooled it
- Ingestible probes for breath-based monitoring of drug-metabolizing activity from the microbiome.Science advances · 2026Article
- Olfactory Science and Technology in Prostate Cancer Diagnosis: From Invertebrate Models to Artificial Intelligence.Life (Basel, Switzerland) · 2026Review
- Real-Time Breath Diagnostics: Linking Molecular Pathways, Measurement Technologies, and Clinical Translation.International journal of molecular sciences · 2026Review
- Induced volatolomics to uncover new enzymatic hallmarks of precancerous lesions: a proof of concept on gastric preneoplasia in mice.Biochemistry and biophysics reports · 2025Article
- Exhalation metabolomics: A new force in revealing the impact of ozone pollution on respiratory health.Eco-Environment & Health · 2024Article
- Fulfilling the Promise of Breathomics: Considerations for the Discovery and Validation of Exhaled Volatile Biomarkers.American journal of respiratory and critical care medicine · 2024Review
- Aggregation-Induced Emission Luminogen: Role in Biopsy for Precision Medicine.Chemical reviews · 2024Review
- Biomarkers in Cancer Screening: Promises and Challenges in Cancer Early Detection.Hematology/oncology clinics of North America · 2024Review
- Induced-volatolomics for the design of tumour activated therapy.Chemical science · 2023Article
- The untargeted urine volatilome for biomedical applications: methodology and volatilome database.Biological procedures online · 2022Review
- 29th Annual GP2A Medicinal Chemistry Conference.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Synthetic biomarkers: a twenty-first century path to early cancer detection.Nature reviews. Cancer · 2021Review
- Synthetic Artificial Apoptosis-Inducing Receptor for On-Demand Deactivation of Engineered Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Unique enzymatic repertoire reveals the tumour.Nature chemistry · 2020Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of efficient protocols for cancer diagnosis remains highly challenging. An emerging approach relies on the detection in exhaled breath of volatile organic compounds (VOC) produced by tumours. In this context, described here is a novel strategy in which a VOC-based probe is converted selectively in malignant tissues, by a tumour-associated enzyme, for releasing the corresponding VOC. The latter is then detected in the exhaled breath as a tumour marker for cancer diagnosis. This approach allows the detection of several different tumours in mice, the monitoring of tumour growth and tumour response to chemotherapy. Thus, the concept of "induced volatolomics" provides a new way to explore biological processes using VOC-based probes that could be adapted to many biomedical applications.
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Registered trials
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