ArticleGenome biology and evolution2019
The Draft Genome of Kochia scoparia and the Mechanism of Glyphosate Resistance via Transposon-Mediated EPSPS Tandem Gene Duplication.
Article in Genome biology and evolution, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 74 citations in OpenAlex.
- FHY3/FAR1 transposable elements generate adaptive genetic variation in the Bassia scoparia genome.Pest management science · 2025Article
- A transposable element insertion in AUX/IAA16 disrupts splicing and causes auxin resistance in Bassia scoparia.The Plant journal : for cell and molecular biology · 2025Article
- A rearranged Amaranthus palmeri extrachromosomal circular DNA confers resistance to glyphosate and glufosinate.The Plant cell · 2025Article
- Current status of community resources and priorities for weed genomics research.Genome biology · 2024Review
- Weed biology and management in the multi-omics era: Progress and perspectives.Plant communications · 2024Review
- Subtelomeric 5-enolpyruvylshikimate-3-phosphate synthase copy number variation confers glyphosate resistance in Eleusine indica.Nature communications · 2023Article
- Weed genomics: yielding insights into the genetics of weedy traits for crop improvement.aBIOTECH · 2023Review
- Subtelomeric 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) copy number variation confers glyphosate resistance in Eleusine indica.Research square · 2023Article
- The Current Developments in Medicinal Plant Genomics Enabled the Diversification of Secondary Metabolites' Biosynthesis.International journal of molecular sciences · 2022Review
- Quantifiable urine glyphosate levels detected in 99% of the French population, with higher values in men, in younger people, and in farmers.Environmental science and pollution research international · 2022Article
- Insights into glucosinolate accumulation and metabolic pathways in Isatis indigotica Fort.BMC plant biology · 2022Article
- Multiple evolutionary origins of glyphosate resistance inEvolutionary applications · 2022Article
- Genomic-based epidemiology reveals independent origins and gene flow of glyphosate resistance in Bassia scoparia populations across North America.Molecular ecology · 2021Article
- Comparing whole-genome shotgun sequencing and DNA metabarcoding approaches for species identification and quantification of pollen species mixtures.Ecology and evolution · 2021Article
- Evolution of Glyphosate-Resistant Weeds.Reviews of environmental contamination and toxicology · 2021Review
- Mechanisms of evolved herbicide resistance.The Journal of biological chemistry · 2020Review
- The EccDNA Replicon: A Heritable, Extranuclear Vehicle That Enables Gene Amplification and Glyphosate Resistance inThe Plant cell · 2020Article
- Omics Potential in Herbicide-Resistant Weed Management.Plants (Basel, Switzerland) · 2019Review
- Population Genomic Approaches for Weed Science.Plants (Basel, Switzerland) · 2019Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increased copy number of the 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) gene confers resistance to glyphosate, the world's most-used herbicide. There are typically three to eight EPSPS copies arranged in tandem in glyphosate-resistant populations of the weed kochia (Kochia scoparia). Here, we report a draft genome assembly from a glyphosate-susceptible kochia individual. Additionally, we assembled the EPSPS locus from a glyphosate-resistant kochia plant by sequencing select bacterial artificial chromosomes from a kochia bacterial artificial chromosome library. Comparing the resistant and susceptible EPSPS locus allowed us to reconstruct the history of duplication in the structurally complex EPSPS locus and uncover the genes that are coduplicated with EPSPS, several of which have a corresponding change in transcription. The comparison between the susceptible and resistant assemblies revealed two dominant repeat types. Additionally, we discovered a mobile genetic element with a FHY3/FAR1-like gene predicted in its sequence that is associated with the duplicated EPSPS gene copies in the resistant line. We present a hypothetical model based on unequal crossing over that implicates this mobile element as responsible for the origin of the EPSPS gene duplication event and the evolution of herbicide resistance in this system. These findings add to our understanding of stress resistance evolution and provide an example of rapid resistance evolution to high levels of environmental stress.
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