Evidence map›Paper›PMID 31518163›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-κB activation in murine macrophages

Bastihalli T Diwakar, Ryan Yoast, Shaneice Nettleford, Fenghua Qian, Tai-Jung Lee, Svanjita Berry, Ian Huffnagle, Randall M Rossi, Mohamed Trebak, Robert F Paulson and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Coactosin-Like Protein Reduces Prostaglandin DAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  2. Article
  3. Review
  4. CRTH2: a potential target for the treatment of organ fibrosis.Acta biochimica et biophysica Sinica · 2022
    Article
  5. Article
  6. Article
  7. Article
  8. Expression of Serum miR-155 in Children withInfection and drug resistance · 2021
    Article
  9. Selenium and selenoproteins in prostanoid metabolism and immunity.Critical reviews in biochemistry and molecular biology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Bastihalli T DiwakarCenter for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.
Ryan YoastDepartment of Cellular and Molecular Physiology, The Penn State College of Medicine, Hershey, Pennsylvania, USA.
Shaneice NettlefordCenter for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.
Fenghua QianCenter for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.
Tai-Jung LeeCenter for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.
Svanjita BerryCenter for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.
Ian HuffnagleCenter for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.
Randall M RossiTransgenic Mouse Facility, Huck Institute of the Life Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.
Mohamed TrebakDepartment of Cellular and Molecular Physiology, The Penn State College of Medicine, Hershey, Pennsylvania, USA.
Robert F PaulsonCenter for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.
K Sandeep PrabhuCenter for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.
Pennsylvania State University · USCenter for Molecular Medicine and Immunology · USPenn State Milton S. Hershey Medical Center · USUniversity of Toledo · US

Funding

High-throughput targeted mutagenesis of mouse stem cell linesU01HG004080 · NHGRI · CHILDREN'S HOSPITAL & RES CTR AT OAKLAND · PI DE JONG, PIETER J. · 2006 to 2010
$28.1M
Production of Targeted Null Mutations for 10,000 Genes in C57BL/6 ES CellsU01HG004085 · NHGRI · REGENERON PHARMACEUTICALS, INC. · PI VALENZUELA, DAVID MANUEL · 2006 to 2010
$25.3M
UCD KOMP PROJECT REPOSITORYU42RR024244 · NCRR · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LLOYD, KC KENT · 2007 to 2010
$7.9M
Receptor-regulated Ca2+ Entry Pathways in Smooth MuscleR01HL097111 · NHLBI · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI TREBAK, MOHAMED · 2010 to 2019
$3.7M
The BMP4 dependent stress erythropoiesis pathway in short-term radioprotectionR01DK080040 · NIDDK · PENNSYLVANIA STATE UNIVERSITY, THE · PI PAULSON, ROBERT FRANK · 2009 to 2017
$2.6M
Cellular Selenium Status and PGJ2 Metabolism (PA-17-078 supplement 2017)R01DK077152 · NIDDK · PENNSYLVANIA STATE UNIVERSITY, THE · PI PRABHU, KUMBLE SANDEEP · 2008 to 2018
$2.5M
Leukotriene C4 and STIM/Orai channels in airway smooth muscle remodelingR01HL123364 · NHLBI · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI TREBAK, MOHAMED · 2014 to 2017
$1.5M
Cellular selenium and PGJ2 metabolismR56DK077152 · NIDDK · PENNSYLVANIA STATE UNIVERSITY, THE · PI PRABHU, KUMBLE SANDEEP · 2021 to 2021
$386k
BMP4 dependent stress erythropoiesis pathway in short-term radioprotectionR56DK080040 · NIDDK · PENNSYLVANIA STATE UNIVERSITY, THE · PI PAULSON, ROBERT FRANK · 2013 to 2013
$75k
NCRR NIH HHS U42 RR024244NHGRI NIH HHS U01 HG004080NHGRI NIH HHS U01 HG004085NHLBI NIH HHS R01 HL097111NHLBI NIH HHS R01 HL123364NIDDK NIH HHS R01 DK077152NIDDK NIH HHS R01 DK080040NIDDK NIH HHS R56 DK077152NIDDK NIH HHS R56 DK080040
6 · The paper itself

Abstract

Prostaglandin D

Indexed as

Down-RegulationSignal TransductionAnimalsCalciumInflammationLipopolysaccharidesMacrophagesMaleMiceMice, Inbred C57BLMice, KnockoutNF-kappa BRAW 264.7 CellsReceptors, ImmunologicReceptors, ProstaglandinCalciumLipopolysaccharidesNF-kappa Bprostaglandin D2 receptorReceptors, ImmunologicReceptors, ProstaglandincAMPcyclopentenone prostaglandinsprotein kinase Aresolution of inflammationselenium

Identifiers

PMID31518163
PMCPMC6988853
OpenAlexW2972466681

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.