ArticleOptics letters2019
Imaging Cherenkov photon emissions in radiotherapy with a Geiger-mode gated quanta image sensor.
Article in Optics letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- Quantitative Cherenkov-excited fluorescence emission dosimetry for HDR Co-60 brachytherapy: Calibration and planar validation against TPS.Journal of applied clinical medical physics · 2026Article
- Review of Cherenkov imaging technology advances in radiotherapy: single-photon-level imaging in high ambient light and radiation backgrounds.Biophotonics discovery · 2024Review
- Detective quantum efficiency of intensified CMOS cameras for Cherenkov imaging in radiotherapy.Physics in medicine and biology · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
The emission of Cherenkov photons from human and animal tissue can be observed during clinical x-ray or particle beam irradiation. However, imaging this weak emission with the necessary single-photon sensitivity in the clinical room is challenging because of milliwatt-level ambient room lighting and the presence of stray high-energy radiation. In this Letter, we demonstrate, to the best of our knowledge, the first Cherenkov imaging with a time-gated quanta image sensor employing a large single-photon avalanche diode (SPAD) array. Detecting single Cherenkov photons was possible with high photon avalanche gain, fast temporal gating, and moderately high ∼7% photon detection probability. Single-bit digitization and active SPAD quenching enabled stray x-ray noise suppression and photon-noise-limited imaging in a clinical environment. This type of imaging allows the knowledge of location, shape, and surface dose of the therapeutic beam radiotherapy with the stability of solid state-based detection.
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Registered trials
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