SynthesisMedicine2019
Prognostic value of pretreatment plasma fibrinogen in patients with colorectal cancer: A systematic review and meta-analysis.
Synthesis in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 32 citations in OpenAlex.
- High Accuracy Stool Biomarkers of Precancerous Colorectal Cancer Identified Using a 2000-Plex Immunoproteomic Screen.Molecular & cellular proteomics : MCP · 2026Article
- Hemorrhage-coagulation immune phenotype is associated with CD163/HO-1-enriched heme-processing macrophage remodeling and predicts recurrence in colorectal cancer: a real-world retrospective cohort study.Frontiers in immunology · 2026Article
- Preoperative blood neutrophil-to-lymphocyte ratio, hematocrit and fibrinogen predict prognosis in colorectal cancer.Biomarkers in medicine · 2025Article
- Fibrinogen-Albumin Ratio: An Independent Recurrence Factor for Colorectal Cancer Stages II and III in a Competing Risk Model.Journal of the anus, rectum and colon · 2025Article
- Article
- Machine learning models to predict systemic inflammatory response syndrome after percutaneous nephrolithotomy.BMC urology · 2024Article
- Ranking as a Procedure for Selecting a Replacement Variable in the Score Predicting the Survival of Patients Treated with Curative Intent for Colorectal Liver Metastases.Medicina (Kaunas, Lithuania) · 2023Article
- A new prognostic model for glioblastoma multiforme based on coagulation-related genes.Translational cancer research · 2023Article
- Relationship between fibrinogen level and advanced colorectal adenoma among inpatients: A retrospective case-control study.Frontiers in medicine · 2023Article
- Multi-clinical index classifier combined with AI algorithm model to predict the prognosis of gallbladder cancer.Frontiers in oncology · 2023Article
- Development and validation of a nomogram based on neutrophil-to-lymphocyte ratio and fibrinogen-to-lymphocyte ratio for predicting recurrence of colorectal adenoma.Journal of gastrointestinal oncology · 2022Article
- Preoperative low absolute lymphocyte count to fibrinogen ratio correlated with poor survival in nonmetastatic colorectal cancer.World journal of surgical oncology · 2022Article
- Fibrinogen levels in relation to colorectal cancer onset: A nested case-cohort study from the Moli-sani cohort.Frontiers in cardiovascular medicine · 2022Article
- The Potential Prognostic Value of a Novel Hematologic Marker Fibrinogen-to-Lymphocyte Ratio in Head and Neck Adenoid-Cystic Carcinoma.Journal of personalized medicine · 2021Article
- Article
- Low plasma fibrinogen levels are associated with poor prognosis in cutaneous angiosarcoma of the head and neck.Cancer science · 2021Article
- The preoperative elevated plasma fibrinogen level is associated with the prognosis of hilar cholangiocarcinoma.Surgery today · 2021Article
- Pretreatment Blood Markers in the Prediction of Occult Neck Metastasis: A 10-Year Retrospective Study.Cureus · 2021Article
- Review
- Validation Study of Fibrinogen and Albumin Score in Esophageal Cancer Patients Who Underwent Esophagectomy: Multicenter Prospective Cohort Study.Annals of surgical oncology · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGrowing evidence showed that high pretreatment plasma fibrinogen could be used as a potential prognostic marker in colorectal cancer (CRC). However, the conclusions were controversial. Therefore, this meta-analysis was conducted to evaluate the prognostic value of pretreatment plasma fibrinogen in patients with CRC.
methodsRelevant studies were searched in the databases including PubMed, EMBASE, Web of Science, Cochrane library, and China National Knowledge Infrastructure up until December 10th, 2018. Pooled hazard ratios (HRs) with their 95% confidence intervals (CIs) were used to estimate the effects.
resultsA total of 17 articles with 6863 patients were included in this meta-analysis. The results revealed that elevated pretreatment plasma fibrinogen was significantly associated with both poor overall survival (univariate analysis: HR = 1.69, 95% CI 1.47-1.95, P = .000; multivariate analysis: HR = 1.50, 95% CI 1.28-1.77, P = .000) and poor disease-free survival (univariate analysis: HR = 1.90, 95% CI 1.49-2.41, P = .000; multivariate analysis: HR = 2.08, 95% CI 1.52-2.86, P = .000) in patients with CRC.
conclusionsHigh pretreatment plasma fibrinogen level is significantly associated with worse survival outcomes in CRC patients. Plasma fibrinogen may be used as an effective prognostic marker and potential therapeutic target. Further studies are required to support these results.
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