ArticleMedical care2019
Research Lifecycle to Increase the Substantial Real-world Impact of Research: Accelerating Innovations to Application.
Article in Medical care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Anticipating implementation: A mixed methods study of future prescribing determinants within an ongoing trial of clinical effectiveness.Implementation science communications · 2026Article
- Structuring Collaboration Between Researchers and Operational Innovators: Diffusing New Practices Across the Veteran's Administration Healthcare System.Learning health systems · 2026Article
- Prenatal therapies: a Points to Consider framework for responsible innovation.BMC medical genomics · 2025Review
- Incorporating Implementation Science Into Frailty Interventions for Cardiovascular Disease.JACC. Advances · 2025Review
- An evidence-informed, community-engaged approach to designing a large-scale, impact-oriented research funding initiative to foster the implementation of transformative integrated care: a multi-methods qualitative study.Implementation science communications · 2025Article
- How senior leaders support innovations in large learning health systems: Insights from United States Veterans Health Administration national program office leaders.Learning health systems · 2025Article
- Factors affecting undergraduate nursing students' professional commitment: a structural equation modeling analysis.BMC nursing · 2025Article
- Charting progress in learning health systems: A systematic review of 5 years of definitions, models, and frameworks.Learning health systems · 2025Article
- The translation-to-policy learning cycle to improve public health.Learning health systems · 2024Article
- Training an Embedded Workforce to Realize Health System Impacts and the Promise of Learning Health Systems Comment on "Early Career Outcomes of Embedded Research Fellows: An Analysis of the Health System Impact Fellowship Program".International journal of health policy and management · 2024Article
- Spreading pride in all who served: A health education program to improve access and mental health outcomes for sexual and gender minority veterans.Psychological services · 2023Article
- Grading Evidence to Support Legislative and Budget Proposals-Veterans Health Administration's Key to Implementing the Evidence Act.Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research · 2023Article
- The Alliance for Healthier Communities' journey to a learning health system in primary care.Learning health systems · 2023Article
- Diffusion of excellence: evaluating a system to identify, replicate, and spread promising innovative practices across the Veterans health administration.Frontiers in health services · 2023Article
- Implementation science: A critical but undervalued part of the healthcare innovation ecosystem.Health care science · 2022Review
- Article
- Designing for Dissemination and Sustainability to Promote Equitable Impacts on Health.Annual review of public health · 2022Review
- Clarifying the concept of a learning health system for healthcare delivery organizations: Implications from a qualitative analysis of the scientific literature.Learning health systems · 2022Article
- Getting To Implementation (GTI)-Teach: A seven-step approach for teaching the fundamentals of implementation science.Journal of clinical and translational science · 2022Article
- Facilitating future implementation and translation to clinical practice: The Implementation Planning Assessment Tool for clinical trials.Journal of clinical and translational science · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUS health care systems face a growing demand to incorporate innovations that improve patient outcomes at a lower cost. Funding agencies increasingly must demonstrate the impact of research investments on public health. The Learning Health System promotes continuous institutional innovation, yet specific processes to develop innovations for further research and implementation into real-world health care settings to maximize health impacts have not been specified.
objectiveWe describe the Research Lifecycle and how it leverages institutional priorities to support the translation of research discoveries to clinical application, serving as a broader operational approach to enhance the Learning Health System.
methodsDeveloped by the US Department of Veterans Affairs Office of Research and Development Research-to-Real-World Workgroup, the Research Lifecycle incorporates frameworks from product development, translational science, and implementation science methods. The Lifecycle is based on Workgroup recommendations to overcome barriers to more direct translation of innovations to clinical application and support practice implementation and sustainability.
resultsThe Research Lifecycle posits 5 phases which support a seamless pathway from discovery to implementation: prioritization (leadership priority alignment), discovery (innovation development), validation (clinical, operational feasibility), scale-up and spread (implementation strategies, performance monitoring), and sustainability (business case, workforce training). An example of how the Research Lifecycle has been applied within a health system is provided.
conclusionsThe Research Lifecycle aligns research and health system investments to maximize real-world practice impact via a feasible pathway, where priority-driven innovations are adapted for effective clinical use and supported through implementation strategies, leading to continuous improvement in real-world health care.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.