ArticleCognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology2019
Changes in Cognitive Performance With Age in Adults With Multiple Sclerosis.
Article in Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effects of exercise in people with multiple sclerosis: a systematic review and meta-analysis.Frontiers in public health · 2024Pooled it
- Driving ability and predictors for driving performance in Multiple Sclerosis: A systematic review.Frontiers in neurology · 2022Pooled it
- Effects of gamma-aminobutyric acid on working memory and attention: A randomized, double-blinded, placebo-controlled, crossover trial.Journal of psychopharmacology (Oxford, England) · 2023Trial
- Clinical and functional profile of very old people with multiple sclerosis: a cross-sectional study in the genoa area.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Aging and the neuropsychiatry of multiple sclerosis: a cross-sectional study.Journal of neurology · 2025Article
- Cognitive-Motor Coupling in Multiple Sclerosis: Do Chronological Age and Physical Activity Matter?Brain sciences · 2025Article
- Effectiveness of Ocrelizumab on Disease Progression and Disability Status in Multiple Sclerosis Patients: A Two-Year Prospective Cohort Study.Journal of clinical medicine · 2025Article
- A multimodal approach to distinguish multiple sclerosis phenotypes at diagnosis using biomarker profiles.Therapeutic advances in neurological disorders · 2025Article
- The contribution of paramagnetic rim and cortical lesions to physical and cognitive disability at multiple sclerosis clinical onset: evaluating the power of MRI and OCT biomarkers.Journal of neurology · 2024Article
- Cognitive Function in Frail Older Adults With Multiple Sclerosis: An Exploratory Study Using Secondary Data Analysis.International journal of MS care · 2024Article
- Management of multiple sclerosis in older adults: review of current evidence and future perspectives.Journal of neurology · 2024Review
- Factors affecting driving performance in patients with Multiple Sclerosis - still an open question.Frontiers in neurology · 2024Article
- Serum and CSF Biomarkers Predict Active Early Cognitive Decline Rather Than Established Cognitive Impairment at the Moment of RRMS Diagnosis.Diagnostics (Basel, Switzerland) · 2022Article
- Cognitive Decline in Older People with Multiple Sclerosis-A Narrative Review of the Literature.Geriatrics (Basel, Switzerland) · 2022Review
- Physical activity and self-reported sleep quality in adults with multiple sclerosis.Disability and health journal · 2021Article
- Demographic, clinical, and symptomatic correlates of subjective sleep quality in adults with multiple sclerosis.Multiple sclerosis and related disorders · 2021Article
- Symptom clusters and quality of life in persons with multiple sclerosis across the lifespan.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Article
- Cognitive Processing Speed Impairment Does Not Influence the Construct Validity of Six-Spot Step Test Performance in People With Multiple Sclerosis.Physical therapy · 2021Article
- Clinical Characteristics and Disability Progression of Early- and Late-Onset Multiple Sclerosis Compared to Adult-Onset Multiple Sclerosis.Journal of clinical medicine · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundCognitive impairment is one of the most common consequences of multiple sclerosis (MS), yet there is a shortage of data regarding how cognition changes during the life span of individuals with MS. This information is of increasing importance given the growing proportion of older adults with MS.
objectiveTo study possible changes in cognitive function in correlation with increasing age in individuals with MS.
methodsParticipants (N=129) were recruited and a priori allocated into one of three age groups (young, middle-aged, and older). All participants completed the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) during a single laboratory testing session. The BICAMS measures cognitive processing speed as well as verbal and visuospatial learning and memory.
resultsA multivariate analysis of variance indicated that cognitive function significantly differed by age group, and these differences were not explained by amount of physical activity, years of education, years since diagnosis, or race. Older adults displayed significantly worse cognitive processing speed than young and middle-aged adults. The older and middle-aged adults also demonstrated significantly worse visuospatial learning and memory than the younger adults. Effect sizes indicated that cognitive processing speed and verbal learning and memory were more affected in late adulthood than early adulthood, whereas visuospatial learning and memory was affected similarly in early and late adulthood.
conclusionsOlder adults with MS demonstrated significant impairments in cognitive function compared to young and middle-aged adults with MS. Future studies should determine the predictors of cognitive decline in this age cohort.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.