ReviewAnesthesia and analgesia2019
Beyond Anesthesia Toxicity: Anesthetic Considerations to Lessen the Risk of Neonatal Neurological Injury.
Review in Anesthesia and analgesia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 43 citations in OpenAlex.
- Intra-operative physiologic interventions associated with postoperative neurological complications in neonates and infants: A secondary analysis of the NECTARINE cohort.European journal of anaesthesiology · 2026Article
- Mode of Anesthesia During Cesarean Section and Neonatal Morbidity and Mortality: A Cohort Study.Local and regional anesthesia · 2026Article
- A Single-Center Descriptive Analysis of Interventions for Hypotension in Children: A Retrospective Cohort Study.Paediatric anaesthesia · 2025Observational
- Oxygenation Practices During General Anesthesia in Pediatric Patients: An International Survey in Europe, USA, Australia, and New Zealand.Paediatric anaesthesia · 2025Article
- Risk factors for and outcomes of intraoperative desaturation in neonates undergoing non-cardiac surgery: a retrospective study.World journal of pediatric surgery · 2025Article
- Anesthesia and Sedation Exposure and Neurodevelopmental Outcomes in Infants Undergoing Congenital Cardiac Surgery: A Retrospective Cohort Study.Anesthesiology · 2023Observational
- First anesthesia exposure effects on short-term neurocognitive function among 1- to 36-month-old children: a case-control pilot study.Translational pediatrics · 2023Article
- Article
- Hypotension and adverse neurodevelopmental outcomes among children with multiple exposures to general anesthesia: Subanalysis of the Mayo Anesthesia Safety in Kids (MASK) Study.Paediatric anaesthesia · 2021Article
- Feasibility of Doppler Ultrasound for Cortical Cerebral Blood Flow Velocity Monitoring During Major Non-cardiac Surgery of Newborns.Frontiers in pediatrics · 2021Article
- Anesthesia management in neonatal congenital bronchobiliary fistula: case report and literature review.BMC anesthesiology · 2020Review
- Opioid-free anesthesia with interfascial dexmedetomidine in a high-risk infant.Saudi journal of anaesthesiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Infants who undergo surgical procedures in the first few months of life are at a higher risk of death or subsequent neurodevelopmental abnormalities. Although the pathogenesis of these outcomes is multifactorial, an understanding of the nature and pathogenesis of brain injury in these infants may assist the anesthesiologist in consideration of their day-to-day practice to minimize such risks. This review will summarize the main types of brain injury in preterm and term infants and their key pathways. In addition, the review will address key potential pathogenic pathways that may be modifiable including intraoperative hypotension, hypocapnia, hyperoxia or hypoxia, hypoglycemia, and hyperthermia. Each of these conditions may increase the risk of perioperative neurological injury, but their long-term ramifications are unclear.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.