ArticleAlzheimer disease and associated disorders
Behaviors Characteristic of Autism Spectrum Disorder in a Geriatric Cohort With Mild Cognitive Impairment or Early Dementia.
Article in Alzheimer disease and associated disorders. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cognitive and brain morphological deviations in middle-to-old aged autistic adults: A systematic review and meta-analysis.Neuroscience and biobehavioral reviews · 2024Pooled it
- Feasibility of Telehealth Occupational Therapy for Behavioral Symptoms of Adults With Dementia: Randomized Controlled Trial.The American journal of occupational therapy : official publication of the American Occupational Therapy Association · 2023Trial
- Autism and Dementia: A Summative Report from the 2nd International Summit on Intellectual Disabilities and Dementia.Journal of autism and developmental disorders · 2026Review
- Autistic Trait Level and Reaction Time in Older Adults: The Influence of Sex and Task upon Study Outcome.Autism in adulthood · 2026Article
- Association of neurodevelopmental conditions with Alzheimer's disease and related dementias and Parkinson's disease.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Association of glymphatic dysfunction, free water, white matter integrity and long-term memory performance in aging autistic adults.Molecular autism · 2026Article
- Convergence and divergence of genes informed by common and rare variants of autism spectrum disorders in tissue-specific pathways and gene networks.Translational psychiatry · 2026Article
- Article
- Protein-Altering Variants' Analysis in Autism Subgroups Uncovers Early Brain-Expressed Gene Modules Relevant to Autism Pathophysiology.Autism research : official journal of the International Society for Autism Research · 2025Article
- Autism, Diagnostics, and Dementia: A Consensus Report From the 2nd International Summit on Intellectual Disabilities and Dementia.International journal of geriatric psychiatry · 2025Review
- Aging Well and Autism: A Narrative Review and Recommendations for Future Research.Healthcare (Basel, Switzerland) · 2024Review
- Frontotemporal neurofibrillary tangles and cerebrovascular lesions are associated with autism spectrum behaviors in late-life dementia.Journal of neurology · 2022Article
- Developmental pyrethroid exposure and age influence phenotypes in a Chd8 haploinsufficient autism mouse model.Scientific reports · 2022Article
- Comparison of behaviors characteristic of autism spectrum disorder behaviors and behavioral and psychiatric symptoms of dementia.Aging & mental health · 2022Article
- Symptomatic, Genetic, and Mechanistic Overlaps between Autism and Alzheimer's Disease.Biomolecules · 2021Review
- The prevalence and incidence of early-onset dementia among adults with autism spectrum disorder.Autism research : official journal of the International Society for Autism Research · 2021Article
- Alterations in Tau Protein Level and Phosphorylation State in the Brain of the Autistic-Like Rats Induced by Prenatal Exposure to Valproic Acid.International journal of molecular sciences · 2021Article
- Role of Neuroinflammation in Autism Spectrum Disorder and the Emergence of Brain Histaminergic System. Lessons Also for BPSD?Frontiers in pharmacology · 2020Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
introductionAutism spectrum disorder (ASD) represents a heterogenous cluster of clinical phenotypes that are classically diagnosed by the time of adolescence. The possibility of late-life emergence of ASD has been poorly explored.
methodsTo more fully characterize the possibility of late-life emergence of behaviors characteristic of ASD in mild cognitive impairment and AD, we surveyed caregivers of 142 older persons with cognitive impairment from the University of Kentucky Alzheimer's Disease Center Longitudinal Cohort using the Gilliam Autism Rating Scale-2.
resultsParticipants with high autism index ratings (autism "possible/very likely," n=23) reported significantly (statistically and clinically) younger age at the onset of cognitive impairment than those who scored in the autism "unlikely" range (n=119): 71.14±10.9 vs. 76.65±8.25 (P=0.034). In addition, those in the autism "possible/very likely" group demonstrated advanced severity of cognitive impairment, indicated by the Clinical Dementia Rating Scale Sum of Boxes scores. DISCUSSION: Data demonstrate that ASD behaviors may seem de novo of degenerative dementia and such behaviors are more prevalent in those with early onset dementia. Further work elucidating a connection between ASD and dementia could shed light on subclinical forms of ASD, identify areas of shared neuroanatomic involvement between ASD and dementias, and provide valuable insights that might hasten the development of therapeutic strategies.
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