Evidence map›Paper›PMID 31517509›Full record

ArticleAmerican journal of respiratory cell and molecular biology2020

Airway Resistance Caused by Sphingomyelin Synthase 2 Insufficiency in Response to Cigarette Smoke.

Gayatri Gupta, Nathalie Baumlin, Justin Poon, Begum Ahmed, Yeun-Po Chiang, Christopher Railwah, Michael D Kim, Melissa Rivas, Hannah Goldenberg, Ziyad Elgamal and 8 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
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  4. Frontiers in endocrinology · 2023
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  6. Genetic pleiotropy between pulmonary function and age-related traits: The Long Life Family Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022
    Article
  7. Update in Chronic Obstructive Pulmonary Disease 2020.American journal of respiratory and critical care medicine · 2021
    Article
  8. Review
  9. Lipids in Chronic Obstructive Pulmonary Disease: A Target for Future Therapy?American journal of respiratory cell and molecular biology · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Gayatri GuptaDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
Nathalie BaumlinDepartment of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas; and.ORCID 0000-0002-5341-6785
Justin PoonDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
Begum AhmedDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
Yeun-Po ChiangDepartment of Cell Biology, and.
Christopher RailwahDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
Michael D KimDepartment of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas; and.
Melissa RivasDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
Hannah GoldenbergDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
Ziyad ElgamalDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
Matthias SalatheDepartment of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas; and.ORCID 0000-0001-9092-4861
Apurav A PanwalaDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
Abdoulaye DaboDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
Chongmin HuanDepartment of Cell Biology, and.
Robert ForonjyDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
Xian-Cheng JiangDepartment of Cell Biology, and.
Raj WadgaonkarDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
Patrick GeraghtyDivision of Pulmonary and Critical Care Medicine, Department of Medicine.ORCID 0000-0003-1647-5505
Pulmonary and Critical Care Associates · USUniversity of Kansas Medical Center · USState University of New York · US

Funding

TRP-mediated airway inflammation by e-cigarette vapingR01HL139365 · NHLBI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SALATHE, MATTHIAS A · 2018 to 2021
$1.8M
NHLBI NIH HHS R01 HL139365
6 · The paper itself

Abstract

Sphingomyelin synthase is responsible for the production of sphingomyelin (SGM), the second most abundant phospholipid in mammalian plasma, from ceramide, a major sphingolipid. Knowledge of the effects of cigarette smoke on SGM production is limited. In the present study, we examined the effect of chronic cigarette smoke on sphingomyelin synthase (SGMS) activity and evaluated how the deficiency of

Indexed as

Airway ResistanceAnimalsBronchiCells, CulturedCeramidesEpithelial CellsGene Expression RegulationHumansMacrophagesMatrix MetalloproteinasesMiceMice, Inbred BALB CMice, Inbred C57BLPhosphorylationProtein Processing, Post-TranslationalProto-Oncogene Proteins c-aktAKT1 protein, humanAkt1 protein, mouseCeramidesMatrix MetalloproteinasesProto-Oncogene Proteins c-aktSgms1 protein, mouseSGMS2 protein, humanSgms2 protein, mouseSmokeSphingomyelinsTransferases (Other Substituted Phosphate Groups)airway restrictionAkt phosphorylationcigarette smokeproteasesphingomyelin synthase

Identifiers

PMID31517509
PMCPMC7055695
OpenAlexW2972767503

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.