Evidence map›Paper›PMID 31517489›Full record

ArticleJournal of medicinal chemistry2019

Targeting of Fumarate Hydratase from

Andrew J Whitehouse, M Daben J Libardo, Monica Kasbekar, Paul D Brear, Gerhard Fischer, Craig J Thomas, Clifton E Barry, Helena I M Boshoff, Anthony G Coyne, Chris Abell

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Design and Synthesis of Novel Antimicrobial Agents.Antibiotics (Basel, Switzerland) · 2023
    Review
  3. Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 3 countries.

Andrew J WhitehouseDepartment of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , U.K.
M Daben J LibardoTuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology , National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda , Maryland 20892 , United States.ORCID 0000-0003-0037-7812
Monica KasbekarNational Center for Advancing Translational Sciences , National Institutes of Health , Bethesda , Maryland 20850 , United States.
Paul D BrearDepartment of Biochemistry , University of Cambridge , Tennis Court Road , Cambridge , CB2 1GA , U.K.
Gerhard FischerDepartment of Biochemistry , University of Cambridge , Tennis Court Road , Cambridge , CB2 1GA , U.K.
Craig J ThomasNational Center for Advancing Translational Sciences , National Institutes of Health , Bethesda , Maryland 20850 , United States.
Clifton E BarryTuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology , National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda , Maryland 20892 , United States.
Helena I M BoshoffTuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology , National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda , Maryland 20892 , United States.ORCID 0000-0002-4333-206X
Anthony G CoyneDepartment of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , U.K.ORCID 0000-0003-0205-5630
Chris AbellDepartment of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , U.K.ORCID 0000-0001-9174-1987
National Institutes of Health · USUniversity of Cambridge · GB

Funding

PATHOGENIC MECHANISMS OF MYCOBACTERIUM TUBERCULOSISZ01AI000693 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI BARRY, CLIFTON · 1993 to 2008
$8.1M
Intramural NIH HHS Z01 AI000693Intramural NIH HHS Z99 AI999999
6 · The paper itself

Abstract

With the growing worldwide prevalence of antibiotic-resistant strains of tuberculosis (TB), new targets are urgently required for the development of treatments with novel modes of action. Fumarate hydratase (fumarase), a vulnerable component of the citric acid cycle in

Indexed as

Drug Delivery SystemsAntitubercular AgentsBinding SitesFumarate HydrataseHumansModels, MolecularMolecular StructureMycobacterium tuberculosisProtein ConformationStructure-Activity RelationshipAntitubercular AgentsFumarate Hydratase

Identifiers

PMID31517489
PMCPMC10478077
OpenAlexW2972798116

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.