ArticleEuropean journal of obstetrics & gynecology and reproductive biology: X2019
Status of VEGF in preeclampsia and its effect on endoplasmic reticulum stress in placental trophoblast cells.
Article in European journal of obstetrics & gynecology and reproductive biology: X, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The trial behind it
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- The Pathogenesis of Preeclampsia: Hypoxia and the Unfolded Protein Response.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
- Redefining Endometrial Decidualization: The Central Role of the ER Stress-Immune-Metabolic Axis.International journal of molecular sciences · 2026Review
- Environmental Toxicants in the Hispanic Community Epigenetically Contributing to Preeclampsia.Cardiovascular toxicology · 2025Review
- Investigation of The Placental Levels of Vascular Endothelial Growth Factor B and Selenoprotein P and Their Relation with Birth Weight in Patients with Pre-eclampsia: A Case-Control Study.International journal of fertility & sterility · 2025Article
- Novel Role of Pin1-Cis P-Tau-ApoE Axis in the Pathogenesis of Preeclampsia and Its Connection with Dementia.Biomedicines · 2024Review
- Nutraceuticals as Modulators of Molecular Placental Pathways: Their Potential to Prevent and Support the Treatment of Preeclampsia.International journal of molecular sciences · 2024Review
- Protein Misfolding in Pregnancy: Current Insights, Potential Mechanisms, and Implications for the Pathogenesis of Preeclampsia.Molecules (Basel, Switzerland) · 2024Review
- Effect of advanced maternal age on ischemic stroke vulnerability in aged rats: Investigating on blood-brain barrier permeability and gene expression.Aging brain · 2024Article
- Article
- MicroRNAs targeting VEGF are related to vascular dysfunction in preeclampsia.Bioscience reports · 2021Article
- Role of Vascular Endothelial Growth Factor (VEGF) in Human Embryo Implantation: Clinical Implications.Biomolecules · 2021Review
- Serum From Preeclamptic Women Triggers Endoplasmic Reticulum Stress Pathway and Expression of Angiogenic Factors in Trophoblast Cells.Frontiers in physiology · 2021Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo explore the role of VEGF in attenuating endoplasmic reticulum stress in placental trophoblast cells. STUDY
designStudy was divided into following parts: 1. Serum Analysis of GRP78 and VEGF using sandwich ELISA. 2. Expression of VEGF and GRP78 in placentae by immunohistochemistry (IHC). 3.
resultsIncreased GRP78 and decreased VEGF protein levels in sera and placentae of preeclamptic pregnant women and reduced expression of various ER stress markers at both transcript and protein levels was observed in trophoblast cells when they were exposed to recombinant VEGF thereby indicating positive role of VEGF in alleviating ER stress.
conclusionsReduced expression of ER stress markers in trophoblast cells against increased VEGF highlighted a new window to explore prospective drugs that can be designed to modulate the activities of various ER stress sensors in order to alleviate ER stress in pregnant women with preeclampsia.
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Registered trials
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