Evidence map›Paper›PMID 31517292›Full record

ArticleInternational journal of pharmaceutics: X2019

Mechanism investigation of ethosomes transdermal permeation.

Xiao-Qian Niu, Dan-Ping Zhang, Qiong Bian, Xing-Fu Feng, Hao Li, Yue-Feng Rao, Yong-Mei Shen, Fu-Neng Geng, An-Ran Yuan, Xiao-Ying Ying and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of pharmaceutics: X, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 124 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Xiao-Qian NiuInstitute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China.
Dan-Ping ZhangInstitute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China.
Qiong BianInstitute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China.
Xing-Fu FengNingbo Saiyusi Biotechnology Co., Ltd., Ningbo 315806, PR China.
Hao LiSanova Bioscience Inc., 42 Nagog Park, STE110, Acton, MA 01741, USA.
Yue-Feng RaoDepartment of Pharmacy, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310058, PR China.
Yong-Mei ShenSichuan Gooddoctor Pharmaceutical Group Co., Ltd, Chengdu 610000, PR China.
Fu-Neng GengSichuan Gooddoctor Pharmaceutical Group Co., Ltd, Chengdu 610000, PR China.
An-Ran YuanInstitute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China.
Xiao-Ying YingInstitute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China.
Jian-Qing GaoInstitute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China.
Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ethosomes are widely used to promote transdermal permeation of both lipophilic and hydrophilic drugs, but the mechanism of interaction between the ethosomes and the skin remains unclear. In this work, it was exploded with several technologies and facilities. Firstly, physical techniques such as attenuated total reflectance fourier-transform infrared and laser confocal Raman were used and the results indicated that the phospholipids configuration of stratum corneum changes from steady state to unstable state with the treatment of ethosomes. Differential scanning calorimetry reflected the thermodynamics change in stratum corneum after treatment with ethosomes. The results revealed that the skin of Bama mini-pigs, which is similar to human skin, treated by ethosomes had a relatively low T

Indexed as

EthosomesLipidMechanismSkinTransdermal delivery

Identifiers

PMID31517292
PMCPMC6733291
OpenAlexW2966569743

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.