ArticleInternational journal of pharmaceutics: X2019
Observation of high-temperature macromolecular confinement in lyophilised protein formulations using terahertz spectroscopy.
Article in International journal of pharmaceutics: X, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Probing the Influence of Water on the Molecular Mobility of PVP/VA using Terahertz Spectroscopy.Molecular pharmaceutics · 2025Article
- Design Principles for Engineering Ionic Liquid-Gold Nanoparticles for Therapeutic Delivery to the Brain.ACS nano · 2025Article
- Characteristic fingerprint spectrum of α-synuclein mutants on terahertz time-domain spectroscopy.Biophysical journal · 2024Article
- Dynamical Transition in Dehydrated Proteins.The journal of physical chemistry letters · 2024Article
- Ionic Liquid-Based Strategy for Predicting Protein Aggregation Propensity and Thermodynamic Stability.JACS Au · 2022Article
- An experimental approach probing the conformational transitions and energy landscape of antibodies: a glimmer of hope for reviving lost therapeutic candidates using ionic liquid.Chemical science · 2021Article
- Terahertz spectroscopy of diabetic and non-diabetic human blood plasma pellets.Journal of biomedical optics · 2021Article
- Exploring conformational preferences of proteins: ionic liquid effects on the energy landscape of avidin.Chemical science · 2020Article
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Authors and funding
9 authors.
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Abstract
Characterising the structural dynamics of proteins and the effects of excipients are critical for optimising the design of formulations. In this work we investigated four lyophilised formulations containing bovine serum albumin (BSA) and three formulations containing a monoclonal antibody (mAb, here mAb1), and explored the role of the excipients polysorbate 80, sucrose, trehalose, and arginine on stabilising proteins. By performing temperature variable terahertz time-domain spectroscopy (THz-TDS) experiments it is possible to study the vibrational dynamics of these formulations. The THz-TDS measurements reveal two distinct glass transition processes in all tested formulations. The lower temperature transition,
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