Evidence map›Paper›PMID 31517274›Full record

ArticleInternational journal of pharmaceutics: X2019

Topical minocycline formulations: Evaluation and comparison of dermal uptake efficacy.

Diana Lac, Maiko Hermsmeier, Xin Chen, Noymi Yam, Akira Yamamoto, Susan Huang, Tanvee Sawant, Kin F Chan, Usha Nagavarapu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of pharmaceutics: X, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Diana LacBioPharmX, Inc., 115 Nicholson Lane, San Jose, CA 95134, USA.
Maiko HermsmeierBioPharmX, Inc., 115 Nicholson Lane, San Jose, CA 95134, USA.
Xin ChenBioPharmX, Inc., 115 Nicholson Lane, San Jose, CA 95134, USA.
Noymi YamBioPharmX, Inc., 115 Nicholson Lane, San Jose, CA 95134, USA.
Akira YamamotoBioPharmX, Inc., 115 Nicholson Lane, San Jose, CA 95134, USA.
Susan HuangBioPharmX, Inc., 115 Nicholson Lane, San Jose, CA 95134, USA.
Tanvee SawantBioPharmX, Inc., 115 Nicholson Lane, San Jose, CA 95134, USA.
Kin F ChanBioPharmX, Inc., 115 Nicholson Lane, San Jose, CA 95134, USA.
Usha NagavarapuBioPharmX, Inc., 115 Nicholson Lane, San Jose, CA 95134, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acne vulgaris is a clinically distinct skin condition with evidence suggesting that inflammation plays a critical role in the pathogenesis of this disorder. Treatment of severe inflammatory acne often involves the use of oral antibiotics, sometimes in combination with topical products. Oral antibiotics often result in systemic side effects and the risks of antibiotic resistance, but no commercial topical minocycline is currently available. We have developed a unique, stable, hydrophilic topical gel formulation with fully solubilized minocycline (MNC-H). Minocycline delivered in our hydrophilic gel remained more stable

Indexed as

AcneAnti-inflammatoryAnti-microbialBPX-01, 2% topical hydrophilic minocycline gelDermalHydrophilicityMNC-H, topical hydrophilic minocycline gel formulationsMNC-L, topical lipophilic minocycline formulationsSkinTetracycline classTransepidermal

Identifiers

PMID31517274
PMCPMC6733297
OpenAlexW2947662425

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.