Evidence map›Paper›PMID 31517148›Full record

ArticleKidney international reports2019

Glucosuria Predicts the Severity of Puumala Hantavirus Infection.

Johanna Tietäväinen, Paula Mantula, Tuula Outinen, Heini Huhtala, Ilkka H Pörsti, Onni Niemelä, Antti Vaheri, Satu Mäkelä, Jukka Mustonen

Open access · goldAbstract read
In one paragraph

Article in Kidney international reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Understanding Renal Tubular Function: Key Mechanisms, Clinical Relevance, and Comprehensive Urine Assessment.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Glucosuria and Prognosis in Acute Kidney Injury.Kidney international reports · 2019
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Johanna TietäväinenFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Paula MantulaDepartment of Internal Medicine, Tampere University Hospital, Tampere, Finland.
Tuula OutinenDepartment of Internal Medicine, Tampere University Hospital, Tampere, Finland.
Heini HuhtalaFaculty of Social Sciences, Tampere University, Tampere, Finland.
Ilkka H PörstiFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Onni NiemeläFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Antti VaheriDepartment of Virology, Medicum, University of Helsinki, Helsinki, Finland.
Satu MäkeläFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Jukka MustonenFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Tampere University · FITampere University · FISeinäjoki University of Applied Sciences · FITampere University Hospital · FIUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPuumala hantavirus (PUUV) causes a mild type of hemorrhagic fever with renal syndrome characterized by acute kidney injury (AKI), increased capillary leakage, and thrombocytopenia. Albuminuria and hematuria in dipstick urine test at hospital admission are known to predict the severity of upcoming AKI.

methodsWe analyzed dipstick urine glucose in 195 patients with acute PUUV infection at hospital admission, and divided them into 2 categories according to the presence or absence of glucose in the dipstick urine test. Determinants of disease severity were analyzed in glucosuric and nonglucosuric patients.

resultsAltogether, 24 of 195 patients (12%) had glucosuria. The patients with glucosuria had more severe AKI than patients without glucosuria (median maximum creatinine concentration 459 μmol/l, range 78-1041 μmol/l vs. 166 μmol/l, range 51-1499 μmol/l;

conclusionGlucosuria is relatively rare, but when present it predicts a more severe disease course in patients with acute PUUV infection.

Indexed as

acute kidney injuryglucosuriahantavirusPuumala virusthrombocytopenia

Identifiers

PMID31517148
PMCPMC6734096
OpenAlexW2947878117

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.