Trial reportScience advances2019
The ferroportin Q248H mutation protects from anemia, but not malaria or bacteremia.
Open access · goldAbstract readClinical TrialMulticenter Study
In one paragraph
Trial report in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Cohort profile: the Entebbe Mother and Baby Study (EMaBS).BMJ open · 2026Trial
- Inhibition of iron overload and ferroptosis attenuates sepsis-induced myocardial injury in mice through STAT3/Lcn2 pathway.Journal of cardiothoracic surgery · 2026Article
- Non-apoptotic Regulated Cell Death Mechanisms in Sepsis and their Therapeutic Potential.Inflammation · 2026Review
- Pharmacologic Inhibition of Erythrocyte Ferroportin Expression ExacerbatesMicroorganisms · 2025Article
- Diagnosis and Management of Non-HFE Hemochromatosis, Ferroportin Disease, and Rare Hereditary Iron-Loading Disorders.Advances in experimental medicine and biology · 2025Review
- Mechanisms controlling cellular and systemic iron homeostasis.Nature reviews. Molecular cell biology · 2024Review
- Article
- RBC membrane biomechanics and Plasmodium falciparum invasion: probing beyond ligand-receptor interactions.Trends in parasitology · 2022Review
- Oral administration of hepcidin and chitosan benefits growth, immunity, and gut microbiota in grass carp (Frontiers in immunology · 2022Article
- β-glucan-coupled superparamagnetic iron oxide nanoparticles induce trained immunity to protect mice against sepsis.Theranostics · 2022Article
- Ethnic Differences in Iron Status.Advances in nutrition (Bethesda, Md.) · 2021Review
- Malaria is a cause of iron deficiency in African children.Nature medicine · 2021Article
- COVID-19 and iron dysregulation: distant sequence similarity between hepcidin and the novel coronavirus spike glycoprotein.Biology direct · 2020Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
32 authors at 9 institutions in 7 countries.
John Muthii MuriukiKenya Medical Research Institute (KEMRI) Wellcome Trust Research Programme, Kilifi, Kenya.ORCID 0000-0003-4369-9547
Alexander J MentzerWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-4502-2209
Gavin BandWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-1710-9024
James J GilchristWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0003-2045-6788
Tommy CarstensenWellcome Sanger Institute, Hinxton, Cambridge, UK.ORCID 0000-0002-3672-9931
Swaib A LuleMedical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda.
Morgan M GoheenMedical Research Council Unit The Gambia at London School of Hygiene and Tropical Medicine, Banjul, The Gambia.ORCID 0000-0003-2297-3295
Fatou JoofMedical Research Council Unit The Gambia at London School of Hygiene and Tropical Medicine, Banjul, The Gambia.
Wandia KimitaKenya Medical Research Institute (KEMRI) Wellcome Trust Research Programme, Kilifi, Kenya.ORCID 0000-0002-3099-7134
Reagan MogireKenya Medical Research Institute (KEMRI) Wellcome Trust Research Programme, Kilifi, Kenya.ORCID 0000-0001-6454-1613
Clare L CutlandMedical Research Council: Respiratory and Meningeal Pathogens Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID 0000-0001-8250-8307
Amidou DiarraCentre de Recherche Action en Sante (GRAS), 06 BP 10248, Ouagadougou 06, Burkina Faso.
Anna RautanenWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Cristina PomillaWellcome Sanger Institute, Hinxton, Cambridge, UK.ORCID 0000-0002-2581-8365
Deepti GurdasaniWellcome Sanger Institute, Hinxton, Cambridge, UK.ORCID 0000-0001-9996-6929
Kirk RockettWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-6369-9299
Neema MturiKenya Medical Research Institute (KEMRI) Wellcome Trust Research Programme, Kilifi, Kenya.ORCID 0000-0002-6585-2074
Francis M NdunguKenya Medical Research Institute (KEMRI) Wellcome Trust Research Programme, Kilifi, Kenya.ORCID 0000-0002-8977-0030
J Anthony G ScottKenya Medical Research Institute (KEMRI) Wellcome Trust Research Programme, Kilifi, Kenya.
Sodiomon B SirimaCentre de Recherche Action en Sante (GRAS), 06 BP 10248, Ouagadougou 06, Burkina Faso.ORCID 0000-0002-0972-4211
Alireza MorovatDepartment of Clinical Biochemistry, Oxford University Hospitals, Oxford, UK.ORCID 0000-0002-5832-7992
Andrew M PrenticeMedical Research Council Unit The Gambia at London School of Hygiene and Tropical Medicine, Banjul, The Gambia.ORCID 0000-0001-5389-451X
Shabir A MadhiMedical Research Council: Respiratory and Meningeal Pathogens Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Emily L WebbLondon School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0002-4019-7456
Alison M ElliottMedical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda.ORCID 0000-0003-2818-9549
Philip BejonKenya Medical Research Institute (KEMRI) Wellcome Trust Research Programme, Kilifi, Kenya.
Manjinder S SandhuWellcome Sanger Institute, Hinxton, Cambridge, UK.
Adrian V S HillWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0003-0900-9629
Dominic P KwiatkowskiWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-5023-0176
Thomas N WilliamsKenya Medical Research Institute (KEMRI) Wellcome Trust Research Programme, Kilifi, Kenya.
Carla CeramiMedical Research Council Unit The Gambia at London School of Hygiene and Tropical Medicine, Banjul, The Gambia.ORCID 0000-0002-7634-0955
Sarah H AtkinsonKenya Medical Research Institute (KEMRI) Wellcome Trust Research Programme, Kilifi, Kenya.ORCID 0000-0002-8360-4402
Kenya Medical Research Institute · KECentre for Human Genetics · GBWellcome Sanger Institute · GBLondon School of Hygiene & Tropical Medicine · GBMRC Unit the Gambia · GMGroupe de Recherche et d’Action sur le Foncier · BFUniversity of the Witwatersrand · ZAOxford University Hospitals NHS Trust · GBUniversity of North Carolina at Chapel Hill · US
Funding
EPA EP-C-15-003Medical Research Council G0600230Medical Research Council G0600718Medical Research Council G0901213Medical Research Council MC_PC_MR/R020183/1Medical Research Council MC_U123292699Medical Research Council MC_U123292700Medical Research Council MC_UU_00026/3Medical Research Council MC_UU_00027/5Medical Research Council MR/K013491/1Medical Research Council MR/M006212/1Medical Research Council MR/P020321/1Medical Research Council MR/R010161/1Medical Research Council MR/R023360/1Medical Research Council MR/S003711/1Medical Research Council MR/S003711/2Wellcome Trust 064693Wellcome Trust 079110Wellcome Trust 095778Wellcome Trust 098051Wellcome Trust 202800/Z/16/ZWellcome Trust 203141Wellcome Trust 204911/Z/16/ZWellcome Trust 206194
Abstract
Iron acquisition is critical for life. Ferroportin (FPN) exports iron from mature erythrocytes, and deletion of the
Indexed as
Iron DeficienciesMutation, MissenseAmino Acid SubstitutionAnemiaBacteremiaCation Transport ProteinsErythrocytesFemaleFerroportinHumansInfantInfant, NewbornIronMalariaMaleCation Transport ProteinsFerroportinIron
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.