Evidence map›Paper›PMID 31516911›Full record

ArticleOrthopaedic journal of sports medicine2019

Predictors of Radiographic Osteoarthritis 2 to 3 Years After Anterior Cruciate Ligament Reconstruction: Data From the MOON On-site Nested Cohort.

MOON Knee Group, Morgan H Jones, Sameer R Oak, Jack T Andrish, Robert H Brophy, Charles L Cox, Warren R Dunn, David C Flanigan, Braden C Fleming, Laura J Huston and 14 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Orthopaedic journal of sports medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Associations Between Patient Characteristics and Cartilage T1ρ Relaxation Times Vary Over Time Following Patellar Dislocation.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 1 institution in 1 country.

MOON Knee Group
Morgan H JonesInvestigation performed at Vanderbilt University, Nashville, Tennessee, USA, and the Cleveland Clinic, Cleveland, Ohio, USA.
Sameer R OakInvestigation performed at Vanderbilt University, Nashville, Tennessee, USA, and the Cleveland Clinic, Cleveland, Ohio, USA.
Jack T AndrishInvestigation performed at Vanderbilt University, Nashville, Tennessee, USA, and the Cleveland Clinic, Cleveland, Ohio, USA.
Robert H BrophyInvestigation performed at Vanderbilt University, Nashville, Tennessee, USA, and the Cleveland Clinic, Cleveland, Ohio, USA.
Charles L CoxInvestigation performed at Vanderbilt University, Nashville, Tennessee, USA, and the Cleveland Clinic, Cleveland, Ohio, USA.
Warren R DunnInvestigation performed at Vanderbilt University, Nashville, Tennessee, USA, and the Cleveland Clinic, Cleveland, Ohio, USA.
David C FlaniganInvestigation performed at Vanderbilt University, Nashville, Tennessee, USA, and the Cleveland Clinic, Cleveland, Ohio, USA.
Braden C FlemingInvestigation performed at Vanderbilt University, Nashville, Tennessee, USA, and the Cleveland Clinic, Cleveland, Ohio, USA.
Laura J HustonInvestigation performed at Vanderbilt University, Nashville, Tennessee, USA, and the Cleveland Clinic, Cleveland, Ohio, USA.
Christopher C KaedingInvestigation performed at Vanderbilt University, Nashville, Tennessee, USA, and the Cleveland Clinic, Cleveland, Ohio, USA.
Michael KoloskyInvestigation performed at Vanderbilt University, Nashville, Tennessee, USA, and the Cleveland Clinic, Cleveland, Ohio, USA.
Gokhan KuyumcuInvestigation performed at Vanderbilt University, Nashville, Tennessee, USA, and the Cleveland Clinic, Cleveland, Ohio, USA.
T Sean LynchInvestigation performed at Vanderbilt University, Nashville, Tennessee, USA, and the Cleveland Clinic, Cleveland, Ohio, USA.
Robert A MagnussenInvestigation performed at Vanderbilt University, Nashville, Tennessee, USA, and the Cleveland Clinic, Cleveland, Ohio, USA.
Matthew J MatavaInvestigation performed at Vanderbilt University, Nashville, Tennessee, USA, and the Cleveland Clinic, Cleveland, Ohio, USA.
Richard D ParkerInvestigation performed at Vanderbilt University, Nashville, Tennessee, USA, and the Cleveland Clinic, Cleveland, Ohio, USA.
Emily K ReinkeInvestigation performed at Vanderbilt University, Nashville, Tennessee, USA, and the Cleveland Clinic, Cleveland, Ohio, USA.
Erica A ScaramuzzaInvestigation performed at Vanderbilt University, Nashville, Tennessee, USA, and the Cleveland Clinic, Cleveland, Ohio, USA.
Matthew V SmithInvestigation performed at Vanderbilt University, Nashville, Tennessee, USA, and the Cleveland Clinic, Cleveland, Ohio, USA.
Carl WinalskiInvestigation performed at Vanderbilt University, Nashville, Tennessee, USA, and the Cleveland Clinic, Cleveland, Ohio, USA.
Rick W WrightInvestigation performed at Vanderbilt University, Nashville, Tennessee, USA, and the Cleveland Clinic, Cleveland, Ohio, USA.
Alexander ZajichekInvestigation performed at Vanderbilt University, Nashville, Tennessee, USA, and the Cleveland Clinic, Cleveland, Ohio, USA.
Kurt P SpindlerInvestigation performed at Vanderbilt University, Nashville, Tennessee, USA, and the Cleveland Clinic, Cleveland, Ohio, USA.
Cleveland Clinic · US

Funding

Prognosis and Predictors of ACL Reconstruction: A Multicenter Cohort StudyR01AR053684 · NIAMS · VANDERBILT UNIVERSITY · PI SPINDLER, KURT PAUL · 2006 to 2020
$8.3M
Meniscus status and activity level after ACLK23AR066133 · NIAMS · CLEVELAND CLINIC LERNER COM-CWRU · PI JONES, MORGAN HERANCOURT · 2015 to 2019
$745k
NIAMS NIH HHS K23 AR066133NIAMS NIH HHS R01 AR053684
6 · The paper itself

Abstract

backgroundMultiple studies have shown that patients are susceptible to posttraumatic osteoarthritis (PTOA) after an anterior cruciate ligament (ACL) injury, even with ACL reconstruction (ACLR). Prospective studies using multivariable analysis to identify risk factors for PTOA are lacking. PURPOSE/HYPOTHESIS: This study aimed to identify baseline predictors of radiographic PTOA after ACLR at an early time point. We hypothesized that meniscal injuries and cartilage lesions would be associated with worse radiographic PTOA using the Osteoarthritis Research Society International (OARSI) atlas criteria. STUDY

designCohort study; Level of evidence, 3.

methodsA total of 421 patients who underwent ACLR returned on-site for standardized posteroanterior semiflexed knee radiography at a minimum of 2 years after surgery. The mean age was 19.8 years, with 51.3% female patients. At baseline, data on demographics, graft type, meniscal status/treatment, and cartilage status were collected. OARSI atlas criteria were used to grade all knee radiographs. Multivariable ordinal regression models identified baseline predictors of radiographic OARSI grades at follow-up.

resultsOlder age (odds ratio [OR], 1.06) and higher body mass index (OR, 1.05) were statistically significantly associated with a higher OARSI grade in the medial compartment. Patients who underwent meniscal repair and partial meniscectomy had statistically significantly higher OARSI grades in the medial compartment (meniscal repair OR, 1.92; meniscectomy OR, 2.11) and in the lateral compartment (meniscal repair OR, 1.96; meniscectomy OR, 2.97). Graft type, cartilage lesions, sex, and Marx activity rating scale score had no significant association with the OARSI grade.

conclusionOlder patients with a higher body mass index who have an ACL tear with a concurrent meniscal tear requiring partial meniscectomy or meniscal repair should be advised of their increased risk of developing radiographic PTOA. Alternatively, patients with an ACL tear with an articular cartilage lesion can be reassured that they are not at an increased risk of developing early radiographic knee PTOA at 2 to 3 years after ACLR.

Indexed as

ACLarticular cartilageknee osteoarthritismeniscal injury

Identifiers

PMID31516911
PMCPMC6719483
OpenAlexW2970997370

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.