Evidence map›Paper›PMID 31516852›Full record

ArticleBiotechnology reports (Amsterdam, Netherlands)2019

Production of metabolites of the anti-cancer drug noscapine using a P450

Luke Richards, Adrian Lutz, David K Chalmers, Ailsa Jarrold, Tim Bowser, Geoffrey W Stevens, Sally L Gras

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biotechnology reports (Amsterdam, Netherlands), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Review
  3. Molecules (Basel, Switzerland) · 2022
    Review
  4. Review
  5. Article
  6. Review
  7. Enzymkatalysierte späte Modifizierungen: Besser spät als nie.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2021
    Review
  8. Enzymatic Late-Stage Modifications: Better Late Than Never.Angewandte Chemie (International ed. in English) · 2021
    Review
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Luke RichardsDepartment of Chemical Engineering, The University of Melbourne, Parkville, VIC, 3010, Australia.
Adrian LutzMetabolomics Australia, School of Botany, The University of Melbourne, Parkville, VIC, 3010, Australia.
David K ChalmersMedicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Pde, Parkville, VIC, 3010, Australia.
Ailsa JarroldSun Pharmaceutical Industries Ltd., Princes Highway, Port Fairy, VIC, 3281, Australia.
Tim BowserImpact Science Consulting, Unit 2/52 Swanston St, Heidelberg Heights, VIC, 3081, Australia.
Geoffrey W StevensDepartment of Chemical Engineering, The University of Melbourne, Parkville, VIC, 3010, Australia.
Sally L GrasDepartment of Chemical Engineering, The University of Melbourne, Parkville, VIC, 3010, Australia.
University of Melbourne · AUMonash University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytochrome P450 enzymes are a promising tool for the late-stage diversification of lead drug candidates and can provide an alternative route to structural modifications that are difficult to achieve with synthetic chemistry. In this study, a library of P450

Indexed as

BiocatalysisCytochrome P450DMSO, dimethyl sulfoxideHydroxylationIPTG, isopropyl β-D-1-thiogalactopyranosideLC-MS/MS, liquid chromatography-tandem mass spectrometryMOPS, 3-(N-morpholino)propanesulfonic acidNADPH, nicotinamide adenine dinucleotide phosphateN-demethylationP450BM3, CYP102A1 from Bacillus megateriumP450, cytochrome P450QTOF, quadrupole time-of-flightSite-directed mutagenesisWT, wild-type

Identifiers

PMID31516852
PMCPMC6728265
OpenAlexW2969506849

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.