Evidence map›Paper›PMID 31516393›Full record

ArticleCancer cell international2019

Development of transplantable B-cell lymphomas in the MHC-defined miniature swine model.

Alec R Andrews, Zhaohui Wang, Robert A Wilkinson, Jay A Fishman, David H Sachs, Nalu Navarro-Alvarez, Christene A Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer cell international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Swine models for translational oncological research: an evolving landscape and regulatory considerations.Mammalian genome : official journal of the International Mammalian Genome Society · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alec R Andrews *1Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA 02129 USA.
Zhaohui Wang *1Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA 02129 USA.
Robert A Wilkinson3Transplant Infectious Disease and Immunocompromised Host Program, MGH Transplant Center and Harvard Medical School, Boston, MA 02114 USA.
Jay A Fishman3Transplant Infectious Disease and Immunocompromised Host Program, MGH Transplant Center and Harvard Medical School, Boston, MA 02114 USA.
David H Sachs1Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA 02129 USA.
Nalu Navarro-Alvarez *1Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA 02129 USA.
Christene A Huang *1Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA 02129 USA.ORCID 0000-0001-9824-5716

Funding

RES FACIL CONST: XENOTRANSPLANTATION, LUNG ALLOGRAFT REJECTION IN SWINEC06RR020135 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI SLAVIN, PETER L · 2004 to 2004
$2.7M
NCRR NIH HHS C06 RR020135
6 · The paper itself

Abstract

backgroundEstablishment of transplantable tumors in clinically relevant large animals allows translational studies of novel cancer therapeutics.

methodsHere we describe the establishment, characterization, and serial transplantation of a naturally occurring B-cell lymphoma derived from a unique, highly inbred sub-line of Massachusetts General Hospital (MGH) major histocompatibility complex (MHC)-defined miniature swine.

resultsThe lymphoblastic cell line (LCL) originated from peripheral blood of a 2.5 year old female swine leukocyte antigen (SLA)

conclusionsThese results indicate the feasibility of developing a large-animal transplantable tumor model using cells derived from spontaneously occurring hematologic malignancies within the highly inbred miniature swine herd.

Indexed as

B-cell lymphoma, preclinical large animal modelSerial transplantation

Identifiers

PMID31516393
PMCPMC6734256

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.