Evidence map›Paper›PMID 31516357›Full record

ArticleSaudi journal of biological sciences2019

The mechanism of lipopolysaccharide administration-induced cognitive function impairment caused by glucose metabolism disorder in adult rats.

Yiri Du, Hongwei Cui, Yunfeng Xiao, Jianbo Li, Engboer Su, Zhipeng Xu, Weidong Mi

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Saudi journal of biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Mechanism of Mongolian MedicineFrontiers in neuroscience · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yiri DuAnesthesiology and Operation Center, The General Hospital of the People's Liberation Army, Beijing 100853, China.
Hongwei CuiClinical Medical Research Center, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China.
Yunfeng XiaoNew Drug Safety Evaluation and Research Center, Inner Mongolia Medical University, Hohhot 010110, China.
Jianbo LiNuclear Medicine Department, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China.
Engboer SuAnesthesiology Department, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China.
Zhipeng XuAnesthesiology and Operation Center, The General Hospital of the People's Liberation Army, Beijing 100853, China.
Weidong MiAnesthesiology and Operation Center, The General Hospital of the People's Liberation Army, Beijing 100853, China.
Inner Mongolia Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This essay aims to make investigation on the mechanism of glucose metabolism disorder and Lipopolysaccharide administration-induced cognitive function impairment in adult rats with surgery.

methodsDivide the objects, 40 male Sprague-Dawley rats at the age of 9 months, into 4 groups. Provide unilateral nephrectomy surgery and/or lipopolysaccharide intraperitoneal injection. Postoperative cognitive function evaluation would be tested by the Morris water maze. Rats with Postoperative Cognitive Dysfunction (POCD) were scanned to analyze the brain glucose metabolism by means of 18F-FDG PET/CT. Phosphatidylinositol 3-Kinase (PI3K), Protein Kinase β (AKT), Insulin Substrates Receptor-2 (IRS-2) and Glucose Transporter 4 (GLUT4) were detected as well. Data will be captured through gene expression in POCD rats via Quantitative Real-Time PCR (QRT-PCR). On the other side, Western Blot was used to measure the expression levels of IRS-2, p-IRS-2, p-PI3K, PI3K, p-AKT, AKT, GLUT4, and p-GLUT4.

resultsDuring the Morris water maze test, the staging time (latency) of rats in each group was becoming short gradually as the training progressed. The incubation time of Day 5 of each group was shorter than that of Day 1 (

conclusionsAdult SD rats cognitive dysfunction model treated with unilateral nephrectomy combined and 100 μg/kg LPS intraperitoneal injection were led to abnormal both brain glucose metabolism and insulin expression. The proved phenomenal results signal pathway-related proteins PI3K, IRS-2, AKT and GLUT4. It reached the conclusion that surgical trauma, rather than anesthesia, leads to impaired cognitive function. PI3K, IRS-2, AKT, and GLUT4pathway of brain can be partial explanations of the pathogenesis of POCD.

Indexed as

18F-FDG PET/CTAGE, Advanced Glycation End productsFDG, FluorodeoxyglucoseGlucose metabolismGLUT4, Glucose Transporter 4IRS-2, Insulin Substrate Receptor-2LPS, LipopolysaccharideMAPK, Mitogen-Activated Protein KinaseOSEM, Ordered Subsets Expectation MaximizationPI3K, IRS-2, AKT, and GLUT4 pathwayPI3K, Phosphatidylinositol 3-KinasePOCD, Postoperative Cognitive DysfunctionPostoperative cognitive dysfunctionQRT-PCR, Quantitative Real-Time PCRROS, Reactive Oxygen SpeciesSurgical traumaSUV, Standard Uptake ValueTLR4, Toll-like Receptor 4

Identifiers

PMID31516357
PMCPMC6734155
OpenAlexW2955200170

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.