ArticleJournal of oral and maxillofacial pathology : JOMFP
An immunohistochemical study of p53 expressions in oral submucous fibrosis.
Article in Journal of oral and maxillofacial pathology : JOMFP. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- P53 and Ki67 Biomarkers are Predictors for Malignant Transformation in Oral Submucous Fibrosis: A Prospective Study.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Computational analysis of phytocompounds inHeliyon · 2024Article
- Expression of Ki67 Biomarker in Oral Submucous Fibrosis with Clinico-Pathological Correlations: A Prospective Study.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- Clinicopathological Correlation of Cyclooxygenase 2 Expression in Oral Submucous Fibrosis: An Immunohistochemical Study.Journal of International Society of Preventive & Community DentistryArticle
- Senescent Fibroblast in Oral Submucous Fibrosis Aids in Disease Progression and Malignant Transformation.Journal of oral and maxillofacial pathology : JOMFPArticle
- Expression of p53 as Potential Biomarker in Oral Submucous Fibrosis: An Immunohistochemical Study.Journal of microscopy and ultrastructureArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe objective of this histopathological study was to identify the expression of tumor suppressor gene p53 and to detect the correlation between p53 expression and the degree of dysplasia in oral submucous fibrosis (OSMF).
methodsA sample size of 30 OSMF patients irrespective of sex was taken up for the study. The tissue samples obtained were subjected to immunohistochemical method to detect p53 protein. The technique used was indirect super sensitive Polymer-HRP IHC detection system. The p53 positive samples were evaluated on a 4-point scale, which ranged from 3+ to negative.
resultsOut of 30 cases 3(10%) cases were negative for p53 expression and 13(43.3%) showed + expression, and 14(46.6%) showed ++ expression. On application of Mantel-Haenszel Chi-Square test a statistically significant
conclusionImmunohistochemistry is a powerful tool to identify distinct patterns of gene expression in premalignant disorders and also Oral Squamous Cell Carcinomas (OSCC) from different populations. In the present study, a significant number of samples of OSMF were positive for p53 protein.
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