ArticleJournal of thrombosis and thrombolysis2020
A case report of severe bleeding due to lupus anticoagulant hypoprothrombinemia syndrome.
Article in Journal of thrombosis and thrombolysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- Lupus anticoagulant hypoprothrombinemia syndrome successfully treated with rituximab - case report.Thrombosis journal · 2026Article
- [Hypoprothrombinemia-lupus anticoagulant syndrome: a case report and literature review].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2024Review
- Patient with lupus anticoagulant caused aPTT prolongation corrected with prednisolone treatment and later anticoagulation treatment due to chronic atrial fibrillation.Clinical case reports · 2023Article
- [Recurrent epistaxis with coagulation disorders in a boy aged 2 years].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Article
- Anaesthetic considerations for patients with antiphospholipid syndrome undergoing non-cardiac surgery.The Journal of international medical research · 2020Article
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6 authors at 1 institution in 1 country.
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Abstract
Association of acquired factor II deficiency and lupus anticoagulant is a rare disease that can be related to sudden, severe or fatal haemorrhage. We present a 74-years-old woman with history of myelodysplastic syndrome, admitted to the Emergency Department due to spontaneous mucocutaneous bleeding. Coagulation assays revealed prolonged prothrombin time and activated partial thromboplastin time with evidence of an immediate acting inhibitor. Antithrombotic therapy usage, drug ingestion, disseminated intravascular coagulation, liver dysfunction and sepsis were excluded. Patient was admitted for close monitoring and etiological evaluation. A comprehensive bleeding diathesis workup was performed showing factor II levels severely decreased and transient positive lupus anticoagulant. Immunosuppression with methylprednisolone lasted for 3 days, followed by prednisolone. After 20 days she was discharged and follow-up was scheduled. Early diagnosis of lupus anticoagulant hypoprothrombinemia syndrome is critical, as it may result in fatal complications if not treated appropriately. There is no consensus regarding the best treatment, most being based on immunosuppression.
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