Evidence map›Paper›PMID 31515722›Full record

ArticleDigestive diseases and sciences2020

Deficient Active Transport Activity in Healing Mucosa After Mild Gastric Epithelial Damage.

Andrea L Matthis, Izumi Kaji, Kristen A Engevik, Yasutada Akiba, Jonathan D Kaunitz, Marshall H Montrose, Eitaro Aihara

Open access · greenAbstract read
In one paragraph

Article in Digestive diseases and sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Milk andAmerican journal of physiology. Gastrointestinal and liver physiology · 2024
    Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Protective Effect of Ocotillol, the Derivate of Ocotillol-Type Saponins inInternational journal of molecular sciences · 2020
    Article
  11. Do Ulcers Heal Structurally and Functionally?Digestive diseases and sciences · 2020
    Article
  12. (Patho-)Physiology of NaFrontiers in physiology · 2019
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Andrea L MatthisDepartment of Pharmacology and Systems Physiology, University of Cincinnati, ML0576, 231 Albert Sabin Way, Cincinnati, OH, 45267, USA.
Izumi KajiDepartment of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Kristen A EngevikDepartment of Pharmacology and Systems Physiology, University of Cincinnati, ML0576, 231 Albert Sabin Way, Cincinnati, OH, 45267, USA.
Yasutada AkibaDepartment of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Jonathan D KaunitzDepartment of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Marshall H MontroseDepartment of Pharmacology and Systems Physiology, University of Cincinnati, ML0576, 231 Albert Sabin Way, Cincinnati, OH, 45267, USA. mhm@uc.edu.
Eitaro AiharaDepartment of Pharmacology and Systems Physiology, University of Cincinnati, ML0576, 231 Albert Sabin Way, Cincinnati, OH, 45267, USA.
University of California, Los Angeles · USSabin Vaccine Institute · USUniversity of Cincinnati · US

Funding

Stem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Alexander Miethke · 2007 to 2026
$24.4M
Duodenal Muscosal Defense MechanismsR01DK054221 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KAUNITZ, JONATHAN D. · 1999 to 2016
$4.4M
Mechanisms of essential calcium signaling during gastric epithelial wound healingR01DK102551 · NIDDK · UNIVERSITY OF CINCINNATI · PI MONTROSE, MARSHALL H · 2015 to 2018
$1.4M
BLRD VA I01 BX001245NIDDK NIH HHS P30 DK078392NIDDK NIH HHS R01 DK054221NIDDK NIH HHS R01 DK102551NIH HHS P30 DK078392
6 · The paper itself

Abstract

backgroundPeptic ulcers recur, suggesting that ulcer healing may leave tissue predisposed to subsequent damage. In mice, we have identified that the regenerated epithelium found after ulcer healing will remain abnormal for months after healing.

aimTo determine whether healed gastric mucosa has altered epithelial function, as measured by electrophysiologic parameters.

methodUlcers were induced in mouse gastric corpus by serosal local application of acetic acid. Thirty days or 8 months after ulcer induction, tissue was mounted in an Ussing chamber. Transepithelial electrophysiologic parameters (short-circuit current, I

resultsIn unperturbed stomach, luminal application of hyperosmolar NaCl transiently dropped I

conclusionHealing gastric mucosa has deficient electrophysiological recovery in response to hypertonic NaCl. TFF2 and NHE2 contribute to I

Indexed as

Wound HealingAcetic AcidAnimalsDisease Models, AnimalElectric ImpedanceEpithelial CellsFemaleGastric MucosaHydrogen-Ion ConcentrationHypertonic SolutionsMaleMice, Inbred C57BLMice, KnockoutRe-EpithelializationSodium ChlorideSodium-Hydrogen ExchangersAcetic AcidHypertonic SolutionsSlc9a2 protein, mouseSodium ChlorideSodium-Hydrogen ExchangersTFF2 protein, mouseTrefoil Factor-2ActinConfocal microscopyEpithelial cellGastricNHE2PhotodamageRepairTFF2UlcerUssing chamber

Identifiers

PMID31515722
PMCPMC7950857
OpenAlexW2972969903

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.