ReviewJournal of neural transmission (Vienna, Austria : 1996)2020
What goes up must come down: insights from studies on descending controls acting on spinal pain processing.
Review in Journal of neural transmission (Vienna, Austria : 1996), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- On the Coexistence of Monitoring and Dampening of Pain Perception During the Fight-or-Flight Response.Cureus · 2026Article
- Massage Regulates Brain Plasticity in Chronic Sciatic Nerve Compression Injury Rats: A Study Based on Resting-State Functional Magnetic Resonance Imaging.Brain and behavior · 2026Article
- Antinociceptive Effect of Cinnamaldehyde in Male Mice: Investigation of the Mechanisms of Action Through In Silico and In Vivo Approaches.Chemistry & biodiversity · 2026Article
- [Pain modulating systems and manual medicine].Orthopadie (Heidelberg, Germany) · 2025Article
- OnabotulinumtoxinA inhibits dysregulation of descending pain modulation following mild traumatic brain injury in mice.The journal of headache and pain · 2025Article
- Bioanalytical considerations for quantification of ondansetron in rat microdialysis study using LC-MS/MS.Microchemical journal : devoted to the application of microtechniques in all branches of science · 2025Article
- Translational validity of quantitative sensory testing in chronic pain neuro-sensitization: guide of use and interpretation in osteoarthritis animal models.Frontiers in pain research (Lausanne, Switzerland) · 2025Review
- A Pluripotent Progression of the Gate Control System Theory of Pain - Modeling Ascending & Descending Pain Pathways as a Lotka-Volterra Coupled Control & Feedback Loop.Journal of pain research · 2025Article
- Pathology of pain and its implications for therapeutic interventions.Signal transduction and targeted therapy · 2024Review
- Opposing Effects on Descending Control of Nociception by µ and κ Opioid Receptors in the Anterior Cingulate Cortex.Anesthesiology · 2024Article
- Effect of Voluntary Exercise on Endogenous Pain Control Systems and Post-traumatic Headache in Mice.The journal of pain · 2023Article
- Age-related changes in peripheral nociceptor function.Neuropharmacology · 2022Article
- Article
- The role of glutamate transporter-1 in firing activity of locus coeruleus neurons and nociception in rats.Experimental brain research · 2021Article
- Painful Cutaneous Electrical Stimulation vs. Heat Pain as Test Stimuli in Conditioned Pain Modulation.Brain sciences · 2020Article
- Advances in the understanding and treatment of pain and headache.Journal of neural transmission (Vienna, Austria : 1996) · 2020Article
- Translational issues in precision medicine in neuropathic pain.Canadian journal of pain = Revue canadienne de la douleur · 2020Review
- Optotagging and characterization of GABAergic rostral ventromedial medulla (RVM) neurons.Molecular painArticle
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Descending controls link higher processing of noxious signals to modulation of spinal cord responses to their noxious inputs. It has become possible to study one key inhibitory system in animals and humans using one painful stimulus to attenuate another distant response and so eliciting diffuse noxious inhibitory controls (DNIC) or the human counterpart, conditioned pain modulation (CPM). Here, we discuss the neuronal pathways in both species, their pharmacology and examine changes in descending controls with a focus on osteoarthritis. We will also discuss the opposing descending facilitatory system. Strong parallels between DNIC and CPM emphasize the possibility of forward and reverse translation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.