Evidence map›Paper›PMID 31515451›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

A network of phosphatidylinositol 4,5-bisphosphate binding sites regulates gating of the Ca

Kuai Yu, Tao Jiang, YuanYuan Cui, Emad Tajkhorshid, H Criss Hartzell

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 75 citations in OpenAlex.

  1. PIPbioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Review
  4. Allosteric coupling between PIPProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Article
  7. Understanding Ion Channel Gating Mechanisms by Molecular Dynamics Simulations.Advances in experimental medicine and biology · 2026
    Review
  8. CaThe journal of physical chemistry. B · 2025
    Article
  9. Article
  10. [Transmembrane protein 16A--a new target for the treatment of airway inflammatory diseases].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025
    Review
  11. Calcium-activated chloride channel TMEM16A opens via pi-helical transition in transmembrane segment 4.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Article
  13. Article
  14. Review
  15. Distinct modulation of calcium-activated chloride channel TMEM16A by drug-binding sites.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  16. The plasma membrane inner leaflet PI(4,5)PNature communications · 2024
    Article
  17. Niclosamide potentiates TMEM16A and induces vasoconstriction.The Journal of general physiology · 2024
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Kuai YuDepartment of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322.
Tao JiangNIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
YuanYuan CuiDepartment of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322.
Emad TajkhorshidNIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801; tajkhors@illinois.edu criss.hartzell@emory.edu.ORCID 0000-0001-8434-1010
H Criss HartzellDepartment of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322; tajkhors@illinois.edu criss.hartzell@emory.edu.ORCID 0000-0002-3393-1528
Emory University · USUniversity of Illinois Urbana-Champaign · US

Funding

WHOLE CELL SIMULATIONP41GM104601 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI TAJKHORSHID, EMAD · 2012 to 2021
$19.0M
Retinal Degeneration and Chloride ChannelsR01EY014852 · NEI · EMORY UNIVERSITY · PI HARTZELL, H. CRISS · 2003 to 2020
$5.7M
Toolkit for High-Resolution Structure and Dynamics of Functional LipidsR01GM123455 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI MORRISSEY, JAMES H., RIENSTRA, CHAD M · 2016 to 2020
$5.0M
Molecular Physiology of TMEM16/Anoctamin ProteinsR01GM132598 · NIGMS · EMORY UNIVERSITY · PI HARTZELL, H. CRISS · 2019 to 2022
$1.5M
Ion Channel and Lipid Scramblase Functions of Anoctamins: Roles in MyopathyR01AR067786 · NIAMS · EMORY UNIVERSITY · PI HARTZELL, H. CRISS · 2015 to 2018
$1.4M
NEI NIH HHS R01 EY014852NIAMS NIH HHS R01 AR067786NIGMS NIH HHS P41 GM104601NIGMS NIH HHS R01 GM123455NIGMS NIH HHS R01 GM132598
6 · The paper itself

Abstract

ANO1 (TMEM16A) is a Ca

Indexed as

Anoctamin-1Binding SitesCalciumCationsCytosolElectrophysiologyHEK293 CellsHumansMolecular ConformationMolecular Dynamics SimulationMutagenesisMutationNeoplasm ProteinsPatch-Clamp TechniquesPhosphatidylinositol 4,5-DiphosphatePhospholipidsANO1 protein, humanAnoctamin-1CalciumCationsNeoplasm ProteinsPhosphatidylinositol 4,5-DiphosphatePhospholipidschloride channelmolecular dynamicsphospholipidprotein–lipid interactionstructure–function

Identifiers

PMID31515451
PMCPMC6778221
OpenAlexW2972868568

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.