Evidence map›Paper›PMID 31515293›Full record

ArticleSexually transmitted infections2020

Aetiology and prevalence of mixed-infections and mono-infections in non-gonococcal urethritis in men: a case-control study.

Stephen J Jordan, Evelyn Toh, James A Williams, Lora Fortenberry, Michelle L LaPradd, Barry P Katz, Byron E Batteiger, David E Nelson, Teresa A Batteiger

Open access · greenAbstract read
In one paragraph

Article in Sexually transmitted infections, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. German evidence- and consensus-based guideline on the management of penile urethritis.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2025
    Guideline
  2. Article
  3. Article
  4. Guidelines and Diagnostic Assays forOpen forum infectious diseases · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Microorganisms · 2023
    Review
  11. Article
  12. Article
  13. Article
  14. Is There Any Relationship betweenInterdisciplinary perspectives on infectious diseases · 2022
    Review
  15. Review
  16. Urethral Microbiota in Men: Association of Haemophilus influenzae and Mycoplasma penetrans With Nongonococcal Urethritis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Stephen J JordanMedicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0003-4063-2566
Evelyn TohMicrobiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
James A WilliamsMedicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Lora FortenberryMicrobiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Michelle L LaPraddBiostatistics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Barry P KatzBiostatistics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Byron E BatteigerMedicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
David E NelsonMicrobiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Teresa A BatteigerMedicine, Indiana University School of Medicine, Indianapolis, Indiana, USA tbatteig@iu.edu.
Indiana University School of Medicine

Funding

Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
The role of the urethral microbiome in idiopathic urethritis in menR01AI116706 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI NELSON, DAVID EMMET · 2016 to 2020
$3.6M
Role of Interferon-gamma in Clearance of Chlamydia trachomatis Infection in WomenK08AI146278 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI JORDAN, STEPHEN J. · 2019 to 2022
$736k
NCATS NIH HHS UL1 TR002529NIAID NIH HHS K08 AI146278NIAID NIH HHS R01 AI116706
6 · The paper itself

Abstract

objectives

methodsWe identified 155 men with NGU and 103 controls. Behavioural and clinical information was obtained and men were tested for

resultsTwelve per cent of NGU cases in which a pathogen was identified had mixed infections, mostly UU coinfections with MG or CT; 27% had IU. In monoinfected NGU cases, 34% had CT, 17% had MG, 11% had UU and 2% had TV. In controls, pathogens were rarely identified, except for UU, which was present in 20%. Comparing cases and controls, NGU was associated with CT and MG monoinfections and mixed infections. UU monoinfection was not associated with NGU and was almost twice as prevalent in controls. Men in both the case and control groups who were younger and who reported no prior NGU diagnosis were more likely to have UU (OR 0.97 per year of age, 95% CI 0.94 to 0.998 and OR 6.3, 95% CI 1.4 to 28.5, respectively).

conclusionsMixed infections are common in men with NGU and most of these are UU coinfections with other pathogens that are well-established causes of NGU. UU monoinfections are not associated with NGU and are common in younger men and men who have never previously had NGU. Almost half of NGU cases are idiopathic.

Indexed as

AdolescentAdultCase-Control StudiesChlamydia trachomatisCoinfectionHumansMaleMiddle AgedMycoplasma genitaliumNeisseria gonorrhoeaePrevalenceTrichomonas vaginalisUreaplasma urealyticumUrethritisYoung Adultchlamydia infectionchlamydia trachomatisepidemiology (general)mycoplasmaurethritis

Identifiers

PMID31515293
PMCPMC7065951
OpenAlexW2972868051

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.