Evidence map›Paper›PMID 31515268›Full record

ArticleThe Journal of biological chemistry2019

A small-molecule competitive inhibitor of phosphatidic acid binding by the AAA+ protein NSF/Sec18 blocks the SNARE-priming stage of vacuole fusion.

Robert P Sparks, Andres S Arango, Matthew L Starr, Zachary L Aboff, Logan R Hurst, David A Rivera-Kohr, Chi Zhang, Kevin A Harnden, Jermaine L Jenkins, Wayne C Guida and 2 more

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Robert P SparksDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.ORCID 0000-0002-0485-8317
Andres S ArangoCenter for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.
Matthew L StarrDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.
Zachary L AboffCenter for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.
Logan R HurstDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.
David A Rivera-KohrDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.
Chi ZhangDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.
Kevin A HarndenDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.
Jermaine L JenkinsStructural Biology and Biophysics Facility, University of Rochester Medical Center, Rochester, New York 14642.
Wayne C GuidaDepartment of Chemistry, University of South Florida, Tampa, Florida 336204.
Emad TajkhorshidDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.
Rutilio A FrattiDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801 rfratti@illinois.edu.
University of Illinois Urbana-Champaign · USUniversity of Rochester Medical Center · USUniversity of South Florida · US

Funding

Synthetic Antigen Binder CoreU54GM087519 · NIGMS · UNIVERSITY OF CHICAGO · PI PEROZO, EDUARDO A · 2010 to 2017
$31.9M
WHOLE CELL SIMULATIONP41GM104601 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI TAJKHORSHID, EMAD · 2012 to 2021
$19.0M
Virology/Immunology CoreP30AI078498 · NIAID · UNIVERSITY OF ROCHESTER · PI DEWHURST, STEPHEN · 2008 to 2018
$14.6M
Multi-scale modeling of gas transport through channels in living cellsU01GM111251 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI BORON, WALTER F, SOMERSALO, ERKKI JAAKKO · 2015 to 2019
$2.9M
Allosteric Regulation of SNAREs and the Rab GEF Mon1 by PhosphoinositidesR01GM101132 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI FRATTI, RUTILIO A · 2012 to 2016
$1.4M
BIAcore T100 for research and drug discovery in RochesterS10RR027241 · NCRR · UNIVERSITY OF ROCHESTER · PI KIELKOPF, CLARA · 2010 to 2010
$365k
NCRR NIH HHS S10 RR027241NIAID NIH HHS P30 AI078498NIGMS NIH HHS P41 GM104601NIGMS NIH HHS R01 GM101132NIGMS NIH HHS U01 GM111251NIGMS NIH HHS U54 GM087519
6 · The paper itself

Abstract

The homeostasis of most organelles requires membrane fusion mediated by

Indexed as

Adenosine TriphosphatasesATPases Associated with Diverse Cellular ActivitiesEthylmaleimideMembrane FusionMembrane LipidsMembrane Transport ProteinsMolecular Dynamics SimulationN-Ethylmaleimide-Sensitive ProteinsPhosphatidic AcidsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSmall Molecule LibrariesSNARE ProteinsSoluble N-Ethylmaleimide-Sensitive Factor Attachment ProteinsVacuolesVesicular Transport ProteinsAdenosine TriphosphatasesATPases Associated with Diverse Cellular ActivitiesEthylmaleimideMembrane LipidsMembrane Transport ProteinsN-Ethylmaleimide-Sensitive ProteinsPhosphatidic AcidsSaccharomyces cerevisiae ProteinsSEC17 protein, S cerevisiaeSEC18 protein, S cerevisiaeSmall Molecule LibrariesSNARE ProteinsSoluble N-Ethylmaleimide-Sensitive Factor Attachment ProteinsVesicular Transport Proteinsmembrane fusionmembrane lipidmembrane traffickingNSFphosphatidic acidSec17Sec18SNARE proteinsα-SNAP

Identifiers

PMID31515268
PMCPMC6873166
OpenAlexW2973019651

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.