ReviewMayo Clinic proceedings2019
Pure Autonomic Failure.
Review in Mayo Clinic proceedings, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Analysis of biomarkers in speculative CNS-enriched extracellular vesicles for parkinsonian disorders: a comprehensive systematic review and diagnostic meta-analysis.Journal of neurology · 2024Pooled it
- Alpha-Synuclein Strain Variability in Body-First and Brain-First Synucleinopathies.Frontiers in aging neuroscience · 2022Pooled it
- Review of published research on primary dysautonomia of domestic animals.The Veterinary record · 2026Review
- A case report of syndrome of inappropriate antidiuretic hormone secretion unveiling hypothalamic involvement in multiple system atrophy.Frontiers in endocrinology · 2026Article
- Hypertensive emergency with vasogenic cerebral edema following droxidopa initiation in pure autonomic failure.Frontiers in neurology · 2026Article
- Multimodal Autonomic Biomarkers Predict Phenoconversion in Pure Autonomic Failure.Annals of clinical and translational neurology · 2025Observational
- The Usefulness of 131 I-MIBG Myocardial Scintigraphy in a Case of Pure Autonomic Failure - First Report in the Literature.Annals of Indian Academy of Neurology · 2025Article
- Orthostatic Hypotension: a clinical marker for the body-first subtype of patients with Parkinson's Disease.NPJ Parkinson's disease · 2024Article
- Abnormal dopamine transporter imaging in pure autonomic failure: a potential biomarker of central nervous system involvement.European journal of neurology · 2024Article
- Primary autonomic failure: a complex case of orthostatic hypotension in a hypertensive elderly patient.European heart journal. Case reports · 2024Article
- Recent Advances and Future Directions in Syncope Management: A Comprehensive Narrative Review.Journal of clinical medicine · 2024Review
- Ethical Considerations for Identifying Individuals in the Prodromal/Early Phase of Parkinson's Disease: A Narrative Review.Journal of Parkinson's disease · 2024Review
- Seed amplification assay of nasal swab extracts for accurate and non-invasive molecular diagnosis of neurodegenerative diseases.Translational neurodegeneration · 2023Review
- Renal Transplantation in Pure Autonomic Failure.Transplantation direct · 2022Article
- Alpha-synuclein Immunization Strategies for Synucleinopathies in Clinical Studies: A Biological Perspective.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022Review
- Conformational strains of pathogenic amyloid proteins in neurodegenerative diseases.Nature reviews. Neuroscience · 2022Review
- Recent advances in establishing fluid biomarkers for the diagnosis and differentiation of alpha-synucleinopathies - a mini review.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Review
- Movement disorder society criteria for the diagnosis of multiple system atrophy-what's new?Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Article
- α-Synuclein Radiotracer Development and In Vivo Imaging: Recent Advancements and New Perspectives.Movement disorders : official journal of the Movement Disorder Society · 2022Review
- RT-QuIC and Related Assays for Detecting and Quantifying Prion-like Pathological Seeds of α-Synuclein.Biomolecules · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Pure autonomic failure (PAF) is a neurodegenerative disorder of the autonomic nervous system clinically characterized by orthostatic hypotension. The disorder has also been known as Bradbury-Eggleston syndrome, named for the authors of the 1925 seminal description. Patients typically present in midlife or later with orthostatic hypotension or syncope. Autonomic failure may also manifest as genitourinary, bowel, and thermoregulatory dysfunction. With widespread involvement, patients may present to a variety of different specialties and require multidisciplinary treatment approaches. Pathologically, PAF is characterized by predominantly peripheral deposition of α-synuclein. However, patients with PAF may progress into other synucleinopathies with central nervous system involvement.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.