Evidence map›Paper›PMID 31514696›Full record

Trial reportStroke2019

Association Between Intravenous Thrombolysis and Anaphylaxis Among Medicare Beneficiaries With Acute Ischemic Stroke.

Mackenzie P Lerario, James C Grotta, Alexander E Merkler, Setareh Salehi Omran, Monica L Chen, Neal S Parikh, Shadi Yaghi, Santosh Murthy, Babak B Navi, Hooman Kamel

Open access · bronzeAbstract readClinical Trial
In one paragraph

Trial report in Stroke, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Mackenzie P LerarioFrom the Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine, NY (M.P.L., A.E.M., S.S.O., M.L.C., S.M., B.B.N., H.K.).
James C GrottaStroke Research Program and Mobile Stroke Unit, Memorial Hermann Hospital, Houston, TX (J.C.G.).
Alexander E MerklerFrom the Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine, NY (M.P.L., A.E.M., S.S.O., M.L.C., S.M., B.B.N., H.K.).
Setareh Salehi OmranFrom the Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine, NY (M.P.L., A.E.M., S.S.O., M.L.C., S.M., B.B.N., H.K.).
Monica L ChenFrom the Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine, NY (M.P.L., A.E.M., S.S.O., M.L.C., S.M., B.B.N., H.K.).
Neal S ParikhDepartment of Neurology, Columbia University Medical Center, NY (S.S.O., N.S.P.).
Shadi YaghiDepartment of Neurology, Alpert Medical School, Brown University, Providence, RI (S.Y.).
Santosh MurthyFrom the Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine, NY (M.P.L., A.E.M., S.S.O., M.L.C., S.M., B.B.N., H.K.).
Babak B NaviFrom the Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine, NY (M.P.L., A.E.M., S.S.O., M.L.C., S.M., B.B.N., H.K.).
Hooman KamelFrom the Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine, NY (M.P.L., A.E.M., S.S.O., M.L.C., S.M., B.B.N., H.K.).
Cornell University · USMIND Research Institute · USColumbia University Irving Medical Center · USMemorial Hermann · US

Funding

AtRial Cardiopathy and Antithrombotic Drugs In prevention After cryptogenicstroke (ARCADIA)U01NS095869 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRODERICK, JOSEPH PAUL, KAMEL, HOOMAN · 2017 to 2022
$22.0M
NEUROEPIDEMIOLOGY TRAINING PROGRAMT32NS007153 · NINDS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GU, YIAN, WILLEY, JOSHUA ZEBADIAH · 1987 to 2023
$6.2M
Stroke Trials Network of Columbia and CornellU24NS107237 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI EDWARD SANDER CONNOLLY, Randolph S Marshall · 2018 to 2026
$3.1M
Left Atrial abNormality, ThromboEmbolism, and Race: Novel risk factors for stroke (LANTERN)R01NS097443 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI KAMEL, HOOMAN · 2016 to 2019
$1.5M
Intracerebral Hemorrhage and Increased Risk of Arterial ThromboembolismK23NS105948 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI MURTHY, SANTOSH BHASKAR · 2018 to 2022
$972k
Cancer And Risk Of Ischemic StrokeK23NS091395 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI NAVI, BABAK BENJAMIN · 2015 to 2019
$945k
NINDS NIH HHS K23 NS091395NINDS NIH HHS K23 NS105948NINDS NIH HHS R01 NS097443NINDS NIH HHS T32 NS007153NINDS NIH HHS U01 NS095869NINDS NIH HHS U24 NS107237
6 · The paper itself

Abstract

Background and Purpose- Allergic reactions, including anaphylaxis, can sometimes occur after intravenous thrombolysis in patients with acute ischemic stroke. However, it remains unclear whether patients with stroke who receive thrombolytic agents face a higher risk of anaphylaxis than those who do not receive thrombolytics. Methods- We performed a retrospective cohort study using inpatient and outpatient claims between 2008 and 2015 from a nationally representative 5% sample of Medicare beneficiaries. We included patients who were ≥65 years old and hospitalized with acute ischemic stroke, defined by validated

Indexed as

AnaphylaxisBrain IschemiaMedicareStrokeAcute DiseaseAgedAged, 80 and overAtrial FibrillationFemaleHumansMaleRetrospective StudiesRisk FactorsThrombolytic TherapyUnited Statesanaphylaxisangioedemaatrial fibrillationmedicarerisk factors

Identifiers

PMID31514696
PMCPMC6863087
OpenAlexW2972317371

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.