Evidence map›Paper›PMID 31514574›Full record

ArticleJournal of the American Heart Association2019

Association Between High-Sensitivity Cardiac Troponin T and Echocardiographic Parameters in Chronic Kidney Disease: Results From the KNOW-CKD Cohort Study.

Eunjeong Kang, Hyunjin Ryu, Jayoun Kim, Joongyub Lee, Kyu-Beck Lee, Dong-Wan Chae, Su Ah Sung, Soo Wan Kim, Curie Ahn, Kook-Hwan Oh

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 19 citations in OpenAlex.

  1. Cardiovascular Disease in CKD: Ethnic and Regional Differences in Risk and Phenotype.Clinical journal of the American Society of Nephrology : CJASN · 2026
    Review
  2. Observational
  3. Review
  4. Review
  5. Article
  6. Cardiac Troponins in Kidney Disease.European cardiology · 2025
    Review
  7. Review
  8. Article
  9. Article
  10. Cardiac biomarkers in pediatric CKD-a prospective follow-up study.Pediatric nephrology (Berlin, Germany) · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Eunjeong KangDepartment of Internal Medicine Seoul National University Hospital Seoul National University College of Medicine Seoul South Korea.
Hyunjin RyuDepartment of Internal Medicine Seoul National University Hospital Seoul National University College of Medicine Seoul South Korea.
Jayoun KimMedical Research Collaborating Center Seoul National University Hospital Seoul National University College of Medicine Seoul South Korea.
Joongyub LeeDepartment of Prevention and Management Inha University Hospital Incheon Korea.
Kyu-Beck LeeDepartment of Internal Medicine School of Medicine Kangbuk Samsung Hospital Sungkyunkwan University Seoul South Korea.
Dong-Wan ChaeDepartment of Internal Medicine Seoul National University Bundang Hospital Seoul National University College of Medicine Seongnam South Korea.
Su Ah SungDepartment of Internal Medicine Nowon Eulji Medical Center Eulji University Seoul South Korea.
Soo Wan KimDepartment of Internal Medicine Chonnam National University Medical School Gwangju South Korea.
Curie AhnDepartment of Internal Medicine Seoul National University Hospital Seoul National University College of Medicine Seoul South Korea.
Kook-Hwan OhDepartment of Internal Medicine Seoul National University Hospital Seoul National University College of Medicine Seoul South Korea.
Seoul National University Hospital · KRChonnam National University · KREulji University · KRInha University Hospital · KRKangbuk Samsung Hospital · KRSeoul National University Bundang Hospital · KRSungkyunkwan University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background It is unclear whether high-sensitivity troponin T (hs-TnT) is associated with subclinical cardiac changes in chronic kidney disease (CKD). We evaluated the relationship between hs-TnT and left ventricular structure and function in a CKD population, according to estimated glomerular filtration rate. Methods and Results We analyzed 2017 patients with CKD stages 1 to 5 (predialysis) in the KNOW-CKD (Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease) cohort. The predictor was hs-TnT level measured at baseline, and the outcomes were left ventricular hypertrophy (LVH) and systolic and diastolic dysfunction shown by echocardiography at baseline and after 4 years. Participants were categorized into quartiles according to hs-TnT levels. The associations between quartiles of hs-TnT and outcomes were assessed using multivariable logistic regression analysis with confounders including demographics, medical history, and laboratory findings. A receiver operating characteristic curve was used to assess the diagnostic power of hs-TnT for the outcomes as a continuous variable. For subgroup analysis, patients were stratified based on an estimated glomerular filtration rate of 60 mL/min per 1.73 m

Indexed as

AdultAgedCohort StudiesDiabetic NephropathiesDiastoleEchocardiographyFemaleGlomerulonephritisHumansHypertension, RenalHypertrophy, Left VentricularMaleMiddle AgedNephritisPolycystic Kidney, Autosomal DominantPrognosisTNNT2 protein, humanTroponin Tchronic kidney diseasediastolic dysfunctionleft ventricular hypertrophytroponin T

Identifiers

PMID31514574
PMCPMC6818004
OpenAlexW2972707504

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.