Evidence map›Paper›PMID 31514570›Full record

ArticleNucleosides, nucleotides & nucleic acids2020

Synthesis and evaluation of the anti-hepatitis B virus activity of 4'-Azido-thymidine analogs and 4'-Azido-2'-deoxy-5-methylcytidine analogs: structural insights for the development of a novel anti-HBV agent.

Kengo Onitsuka, Ryoh Tokuda, Nobuyo Kuwata-Higashi, Hiroki Kumamoto, Manabu Aoki, Masayuki Amano, Satoru Kohgo, Debananda Das, Kazuhiro Haraguchi, Hiroaki Mitsuya and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nucleosides, nucleotides & nucleic acids, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Antiviral nucleoside analogs.Chemistry of heterocyclic compounds · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kengo OnitsukaDepartment of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan.
Ryoh TokudaDepartment of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan.
Nobuyo Kuwata-HigashiDepartment of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Tokyo, Japan.
Hiroki KumamotoDepartment of Pharmaceutical Sciences, Nihon Pharmaceutical University, Saitama, Japan.
Manabu AokiExperimental Retrovirology Section, HIV & AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Masayuki AmanoDepartments of Infectious Diseases and Hematology, Kumamoto University School of Medicine, Kumamoto, Japan.
Satoru KohgoDepartment of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Tokyo, Japan.
Debananda DasExperimental Retrovirology Section, HIV & AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Kazuhiro HaraguchiDepartment of Pharmaceutical Sciences, Nihon Pharmaceutical University, Saitama, Japan.
Hiroaki MitsuyaDepartment of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Tokyo, Japan.
Shuhei ImotoDepartment of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan.

Funding

Development of Novel Agents Active against Hepatitis B VirusZIABC011486 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI MITSUYA, HIROAKI · 2013 to 2025
$3.0M
Intramural NIH HHS ZIA BC011486
6 · The paper itself

Abstract

Hepatitis B virus (HBV) infection is a major worldwide health problem that requires the development of improved antiviral therapies. Here, a series of 4'-Azido-thymidine/4'-Azido-2'-deoxy-5-methylcytidine derivatives (

Indexed as

Antiviral AgentsCytidineHepatitis B virusHep G2 CellsHumansMicrobial Sensitivity TestsMolecular ConformationStereoisomerismZidovudine4'-azidothymidine5-methylcytidineAntiviral AgentsCytidineZidovudine4′-azido nucleosideAnti-HBV nucleosidemodified pyrimidines

Identifiers

PMID31514570
PMCPMC8191380

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.