Evidence map›Paper›PMID 31514437›Full record

ArticleInternational journal of molecular sciences2019

Different Routes to Inhibit Fatty Acid Amide Hydrolase: Do All Roads Lead to the Same Place?

Giacomo Giacovazzo, Tiziana Bisogno, Fabiana Piscitelli, Roberta Verde, Sergio Oddi, Mauro Maccarrone, Roberto Coccurello

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. The Interplay between the Endocannabinoid System, Epilepsy and Cannabinoids.International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Giacomo GiacovazzoFondazione Santa Lucia IRCCS, Preclinical Neuroscience, Via del Fosso di Fiorano 64, 00143 Rome, Italy.
Tiziana BisognoEndocannabinoid Research Group, Institute of Translational Pharmacology, CNR, Via Fosso del Cavaliere 100, 00133 Rome, Italy.
Fabiana PiscitelliEndocannabinoid Research Group, Institute of Biomolecular Chemistry, CNR, Via C. Flegrei 34, 80078 Pozzuoli, Italy.
Roberta VerdeEndocannabinoid Research Group, Institute of Biomolecular Chemistry, CNR, Via C. Flegrei 34, 80078 Pozzuoli, Italy.
Sergio OddiFondazione Santa Lucia IRCCS, Preclinical Neuroscience, Via del Fosso di Fiorano 64, 00143 Rome, Italy.
Mauro MaccarroneFondazione Santa Lucia IRCCS, Preclinical Neuroscience, Via del Fosso di Fiorano 64, 00143 Rome, Italy. m.maccarrone@unicampus.it.
Roberto CoccurelloFondazione Santa Lucia IRCCS, Preclinical Neuroscience, Via del Fosso di Fiorano 64, 00143 Rome, Italy. roberto.coccurello@cnr.it.
Fondazione Santa Lucia · ITInstitute for Complex Systems · ITIstituto di Farmacologia Traslazionale · ITUniversità Campus Bio-Medico · ITUniversity of Teramo · IT

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca 2015KMMKBN
6 · The paper itself

Abstract

There is robust evidence indicating that enhancing the endocannabinoid (eCB) tone has therapeutic potential in several brain disorders. The inhibition of eCBs degradation by fatty acid amide hydrolase (FAAH) blockade, is the best-known option to increase

Indexed as

AmidohydrolasesAnimalsBenzamidesCarbamatesCerebellumEndocannabinoidsEnzyme InhibitorsFatty Acid Amide HydrolasesHippocampusLiverMaleMice, Inbred C57BLPyridazinesUreaAmidohydrolasesBenzamidesCarbamatescyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl esterEndocannabinoidsEnzyme InhibitorsFatty Acid Amide HydrolasesN-pyridazin-3-yl-4-(3-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzylidene)piperidine-1-carboxamidePyridazinesUreaendocannabinoid tonefatty acid amide hydrolaseintranasal drug deliverypatients’ compliancePF-04457845URB597

Identifiers

PMID31514437
PMCPMC6771131
OpenAlexW2972667690

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.