Evidence map›Paper›PMID 31514344›Full record

ReviewJournal of clinical medicine2019

Dry Eye Disease: Emerging Approaches to Disease Analysis and Therapy.

Mostafa Heidari, Farsad Noorizadeh, Kevin Wu, Takenori Inomata, Alireza Mashaghi

2 registry-linked trialsAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 36 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05923528 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Comparison of Non-pharmaceutical Treatments for Evaporative Dry Eye: A Randomized Controlled Study

TypeinterventionalSponsorHe Eye HospitalRan2023 to 2023Enrolled116ConditionsDry EyeArmsIPL, Heated eye mask, LipiFlow®, EyePeace®
NCT06158997 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Safety and Effectiveness of EyePeace on Signs and Symptoms of Dry Eye Disease

TypeinterventionalSponsorHe Eye HospitalRan2023 to 2024Enrolled60ConditionsEvaporative Dry EyeArmsEyePeace, Heated Eye Mask
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Review
  7. CD8American journal of translational research · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Targeting the Gut-Eye Axis: An Emerging Strategy to Face Ocular Diseases.International journal of molecular sciences · 2023
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mostafa HeidariBasir Eye Health Research Center, Tehran 1418643561, Iran. mostafahaidari70@yahoo.com.
Farsad NoorizadehBasir Eye Health Research Center, Tehran 1418643561, Iran. farsadnoorizadeh@gmail.com.ORCID 0000-0003-3393-6369
Kevin WuDepartment of Ophthalmology, Icahn School of Medicine at Mount Sinai, Ophthalmic Consultation Service, New York, NY 10029, USA.
Takenori InomataDepartment of Ophthalmology, Juntendo University Faculty of Medicine, Tokyo 1130033, Japan. tinoma@juntendo.ac.jp.ORCID 0000-0003-3435-1055
Alireza MashaghiSystems Biomedicine and Pharmacology Division, Leiden Academic Centre for Drug Research, Leiden University, 2333CC Leiden, The Netherlands. a.mashaghi.tabari@lacdr.leidenuniv.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dry eye disease (DED) is among the most common ocular disorders affecting tens of millions of individuals worldwide; however, the condition remains incompletely understood and treated. Valuable insights have emerged from multidisciplinary approaches, including immunometabolic analyses, microbiome analyses, and bioengineering. Furthermore, we have seen new developments in clinical assessment approaches and treatment strategies in the recent past. Here, we review the emerging frontiers in the pathobiology and clinical management of DED.

Indexed as

clinical signsDED treatmentdry eye diseaseeye-on-a-chipimmunometabolismmicrobiotaomics

Identifiers

PMID31514344
PMCPMC6780511

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.