ArticleInternational journal of molecular sciences2019
Deficiency of Mitochondrial Aspartate-Glutamate Carrier 1 Leads to Oligodendrocyte Precursor Cell Proliferation Defects Both In Vitro and In Vivo.
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Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
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Who cites it
18 citing papers in PubMed, 22 citations in OpenAlex.
- Endothelial SLC25A13 links glutamine metabolism to angiogenesis.EMBO molecular medicine · 2026Article
- SLC25A12 mitigates mitochondrial dysfunction in myoblast senescence, and alleviates cuproptosis-related changes under copper stress.Biology direct · 2026Article
- Combined ketone body and glutamine supplementation restores aerobic energy production in AGC1-deficient neuronal progenitors.Cell death & disease · 2025Article
- Exploration of the Neuromodulatory Properties of Fyn and GSK-3β Kinases Exploiting 7-Azaindole-Based Inhibitors.Journal of medicinal chemistry · 2025Article
- Aspartate in the Brain: A Review.Neurochemical research · 2025Review
- Developmental and Epileptic Encephalopathy: Pathogenesis of Intellectual Disability Beyond Channelopathies.Biomolecules · 2025Review
- Impact of Histone Acetyltransferases and Histone Deacetylases on Adult Brain Myelin Plasticity.Results and problems in cell differentiation · 2025Review
- Calcium signaling in mitochondrial intermembrane space.Biochemical Society transactions · 2024Review
- Integrating a quinone substructure into histone deacetylase inhibitors to cope with Alzheimer's disease and cancer.RSC medicinal chemistry · 2024Article
- Transcriptional and metabolic effects of aspartate-glutamate carrier isoform 1 (AGC1) downregulation in mouse oligodendrocyte precursor cells (OPCs).Cellular & molecular biology letters · 2024Article
- The role of glutamate and glutamine metabolism and related transporters in nerve cells.CNS neuroscience & therapeutics · 2024Review
- AGC1 Deficiency: Pathology and Molecular and Cellular Mechanisms of the Disease.International journal of molecular sciences · 2022Review
- Aspartate availability limits hematopoietic stem cell function during hematopoietic regeneration.Cell stem cell · 2021Article
- Histone Acetylation Defects in Brain Precursor Cells: A Potential Pathogenic Mechanism Causing Proliferation and Differentiation Dysfunctions in Mitochondrial Aspartate-Glutamate Carrier Isoform 1 Deficiency.Frontiers in cellular neuroscience · 2021Article
- Diseases Caused by Mutations in Mitochondrial Carrier GenesBiomolecules · 2020Review
- Amino Acids Transport and Metabolism 2.0.International journal of molecular sciences · 2020Article
- Glutamate Carrier Involvement in Mitochondrial Dysfunctioning in the Brain White Matter.Frontiers in molecular biosciences · 2020Article
- Mitochondrial Carriers for Aspartate, Glutamate and Other Amino Acids: A Review.International journal of molecular sciences · 2019Review
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Authors and funding
17 authors at 4 institutions in 1 country.
Sabrina PetrallaDepartment of Pharmacy and BioTechnology, University of Bologna, 40126 Bologna, Italy. sabrina.petralla2@unibo.it.
Luis Emiliano Peña-AltamiraDepartment of Pharmacy and BioTechnology, University of Bologna, 40126 Bologna, Italy. luis_emiliano.pena_altamira@kcl.ac.uk.ORCID 0000-0002-8376-027X
Eleonora PoetaDepartment of Pharmacy and BioTechnology, University of Bologna, 40126 Bologna, Italy. eleonora.poeta3@unibo.it.
Francesca MassenzioDepartment of Pharmacy and BioTechnology, University of Bologna, 40126 Bologna, Italy. francesca.massenzio@kcl.ac.uk.
Marco VirgiliDepartment of Pharmacy and BioTechnology, University of Bologna, 40126 Bologna, Italy. marco.virgili@unibo.it.
Simona Nicole BarileDepartment of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, 70121 Bari, Italy.
Luigi SbanoDepartment of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121 Ferrara, Italy. sbnlgu@unife.it.
Emanuela ProfiloDepartment of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, 70121 Bari, Italy. emanuela.profilo@hotmail.it.
Mariangela CorricelliDepartment of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121 Ferrara, Italy. crrmng@unife.it.
Alberto DaneseDepartment of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121 Ferrara, Italy. dnslrt@unife.it.ORCID 0000-0002-0833-9987
Carlotta GiorgiDepartment of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121 Ferrara, Italy. grgclt@unife.it.
Rita OstanDepartment of Experimental, Diagnostic and Specialty Medicine (DIMES, Dipartimento di Medicina Specialistica Diagnostica e Sperimentale) and C.I.G. Interdepartmental Centre "L. Galvani", University of Bologna, 40126 Bologna, Italy. rita.ostan3@unibo.it.ORCID 0000-0002-0299-2811
Miriam CapriDepartment of Experimental, Diagnostic and Specialty Medicine (DIMES, Dipartimento di Medicina Specialistica Diagnostica e Sperimentale) and C.I.G. Interdepartmental Centre "L. Galvani", University of Bologna, 40126 Bologna, Italy. miriam.capri@unibo.it.
Paolo PintonDepartment of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121 Ferrara, Italy. paolo.pinton@unife.it.ORCID 0000-0001-7108-6508
Ferdinando PalmieriDepartment of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, 70121 Bari, Italy. ferdpalmieri@gmail.com.
Francesco Massimo LasorsaInstitute of Biomembranes, Bioenergetics and Molecular Biotechnologies IBIOM, CNR, 70126 Bari, Italy. fm.lasorsa@ibiom.cnr.it.
Barbara MontiDepartment of Pharmacy and BioTechnology, University of Bologna, 40126 Bologna, Italy. b.monti@unibo.it.ORCID 0000-0003-0330-482X
University of Bologna · ITUniversity of Ferrara · ITInstitute of Biomembranes, Bioenergetics and Molecular Biotechnologies · ITUniversity of Bari Aldo Moro · IT
Funding
Consiglio Nazionale delle Ricerche OMIxAGC1DFondazione Telethon GGP11139
Abstract
Aspartate-Glutamate Carrier 1 (AGC1) deficiency is a rare neurological disease caused by mutations in the solute carrier family 25, member 12 (
Indexed as
Adenosine TriphosphateAmino Acid Transport Systems, AcidicAnimalsAntiportersCell DifferentiationCell LineCell ProliferationDown-RegulationGene SilencingLactatesLateral VentriclesMembrane Potential, MitochondrialMiceMitochondriaNeuronsOligodendrocyte Precursor CellsAdenosine TriphosphateAmino Acid Transport Systems, AcidicAntiportersaspartate-glutamate carrierLactatesPlatelet-Derived Growth Factorplatelet-derived growth factor AReactive Oxygen SpeciesReceptors, Transforming Growth Factor betaTransforming Growth Factor betaAGC1 deficiencygrowth factorsmitochondrial diseasemouse modelsubventricular zone
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