Evidence map›Paper›PMID 31514194›Full record

GuidelineHormone research in paediatrics2019

Diagnosis, Genetics, and Therapy of Short Stature in Children: A Growth Hormone Research Society International Perspective.

Paulo F Collett-Solberg, Geoffrey Ambler, Philippe F Backeljauw, Martin Bidlingmaier, Beverly M K Biller, Margaret C S Boguszewski, Pik To Cheung, Catherine Seut Yhoke Choong, Laurie E Cohen, Pinchas Cohen and 25 more

Open access · hybridAbstract readPractice GuidelineReview
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Hormone research in paediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 185 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
185citing papers in PubMed, 5 pooled it
24.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

185 citing papers in PubMed, 5 syntheses or guidelines pooled it, 337 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. A Proposal to Develop New References for Serum IGF-I Levels in ChildrenJournal of clinical research in pediatric endocrinology · 2020
    Guideline
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Analysis of Genetic Factors in a Family With Short Stature.Molecular genetics & genomic medicine · 2026
    Article
  12. Article
  13. Healthy short stature.Archives of endocrinology and metabolism · 2026
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

125 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors at 20 institutions in 15 countries.

Paulo F Collett-SolbergDisciplina de Endocrinologia, Departamento de Medicina Interna, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil, paulosolberg@yahoo.com.
Geoffrey AmblerInstitute of Endocrinology and Diabetes, The University of Sydney, Sydney, New South Wales, Australia.
Philippe F BackeljauwDivision of Endocrinology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Martin BidlingmaierEndocrine Laboratory, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany.
Beverly M K BillerNeuroendocrine Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Margaret C S BoguszewskiDepartment of Pediatrics, Federal University of Parana, Curitiba, Brazil.
Pik To CheungPaediatric Endocrinology, Genetics, and Metabolism, Virtus Medical Group and The University of Hong Kong, Hong Kong SAR, China.
Catherine Seut Yhoke ChoongDepartment of Endocrinology, Perth Children's Hospital, Child and Adolescent Health Service, Perth, Washington, Australia.
Laurie E CohenDivision of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Pinchas CohenLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
Andrew DauberDivision of Endocrinology, Children's National Health System, Washington, District of Columbia, USA.
Cheri L DealEndocrine and Diabetes Service, CHU Sainte-Justine and University of Montreal, Montreal, Québec, Canada.
Chunxiu GongEndocrinology, Genetics, and Metabolism, Beijing Diabetes Center for Children and Adolescents, Medical Genetics Department, Beijing Children's Hospital, Beijing, China.
Yukihiro HasegawaDivision of Endocrinology and Metabolism, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.
Andrew R HoffmanDepartment of Medicine, Stanford University School of Medicine and VA Palo Alto Health Care System, Palo Alto, California, USA.
Paul L HofmanLiggins Institute, University of Auckland, Auckland, New Zealand.
Reiko HorikawaDivision of Endocrinology and Metabolism, National Center for Child Health and Development, Tokyo, Japan.
Alexander A L JorgeUnidade de Endocrinologia Genética (LIM25), Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Anders JuulDepartment of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Peter KamenickýService d'Endocrinologie et des Maladies de la Reproduction, Hôpital de Bicêtre, Assistance Publique-Hôpitaux de Paris, Université Paris-Saclay, Paris, France.
Vaman KhadilkarHirabai Cowasji Jehangir Medical Research Institute (HCJMRI), Jehangir Hospital, Pune, India.
John J KopchickEdison Biotechnology Institute and Department of Biomedical Sciences, HCOM Ohio University Athens, Athens, Ohio, USA.
Berit KriströmInstitute of Clinical Science, Pediatrics, Umeå University, Umeå, Sweden.
Maria de Lurdes A LopesUnidade de Endocrinologia Pediátrica, Area da Mulher, Criança e Adolescente, Centro Hospitalar Universitário de Lisboa Central-Hospital de Dona Estefânia, Lisbon, Portugal.
Xiaoping LuoDepartment of Pediatrics, Tongji Hospital, Tongji Medical Colleage, Huazhong University of Science and Technology, Wuhan, China.
Bradley S MillerDivision of Endocrinology, Department of Pediatrics, University of Minnesota Masonic Children's Hospital, Minneapolis, Minnesota, USA.
Madhusmita MisraDivision of Pediatric Endocrinology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Irene NetchineExplorations Fonctionnelles Endocriniennes, AP-HP Hôpital Trousseau, Centre de Recherche Saint Antoine, INSERM, Sorbonne Université, Paris, France.
Sally RadovickDepartment of Pediatrics, Robert Wood Johnson Medical School, Child Health Institute of New Jersey-Rutgers University, New Brunswick, New Jersey, USA.
Michael B RankeUniversity Children´s Hospital, Tübingen, Germany.
Alan D RogolDepartment of Pediatrics, University of Virginia, Charlottesville, Virginia, USA.
Ron G RosenfeldOregon Health and Science University, Portland, Oregon, USA.
Paul SaengerNYU Winthrop Hospital, Mineola, New York, USA.
Jan M WitDepartment of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands.
Joachim WoelflePediatric Endocrinology Division, Children's Hospital, University of Bonn, Bonn, Germany.
Harvard University · USBeijing Children’s Hospital · CNBoston Children's Hospital · USCentre Hospitalier Universitaire Sainte-Justine · CAChildren's National · USCincinnati Children's Hospital Medical Center · USHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRHospital de Dona Estefânia · PTInserm · FRJehangir Hospital · INLeiden University Medical Center · NLLMU Klinikum · DENational Center For Child Health and Development · JPOhio University · USOregon Health & Science University · USRutgers, The State University of New Jersey · USThe Kids Research Institute Australia · AUThe University of Sydney · AUTokyo Metropolitan Children's Medical Center · JPTongji Hospital · CN

Funding

Modulating Growth Hormone Action as a Target for Improved Health and LongevityR01AG059779 · NIA · OHIO UNIVERSITY ATHENS · PI John Joseph Kopchick · 2018 to 2026
$4.7M
NIA NIH HHS R01 AG059779
6 · The paper itself

Abstract

The Growth Hormone Research Society (GRS) convened a Workshop in March 2019 to evaluate the diagnosis and therapy of short stature in children. Forty-six international experts participated at the invitation of GRS including clinicians, basic scientists, and representatives from regulatory agencies and the pharmaceutical industry. Following plenary presentations addressing the current diagnosis and therapy of short stature in children, breakout groups discussed questions produced in advance by the planning committee and reconvened to share the group reports. A writing team assembled one document that was subsequently discussed and revised by participants. Participants from regulatory agencies and pharmaceutical companies were not part of the writing process. Short stature is the most common reason for referral to the pediatric endocrinologist. History, physical examination, and auxology remain the most important methods for understanding the reasons for the short stature. While some long-standing topics of controversy continue to generate debate, including in whom, and how, to perform and interpret growth hormone stimulation tests, new research areas are changing the clinical landscape, such as the genetics of short stature, selection of patients for genetic testing, and interpretation of genetic tests in the clinical setting. What dose of growth hormone to start, how to adjust the dose, and how to identify and manage a suboptimal response are still topics to debate. Additional areas that are expected to transform the growth field include the development of long-acting growth hormone preparations and other new therapeutics and diagnostics that may increase adult height or aid in the diagnosis of growth hormone deficiency.

Indexed as

Growth DisordersHuman Growth HormoneChildHumansHuman Growth HormoneGrowthGrowth hormoneGuidelinePediatricsTreatment

Identifiers

PMID31514194
PMCPMC6979443
OpenAlexW2973019498

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.