Evidence map›Paper›PMID 31513922›Full record

ArticleEuropean journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences2019

End-point modification of recombinant thrombomodulin with enhanced stability and anticoagulant activity.

Xia Liu, Mallorie Boron, Yu Zhao, Xue-Long Sun

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Xia LiuDepartment of Chemistry, Chemical and Biomedical Engineering and Center for Gene Regulation in Health and Disease (GRHD), Cleveland State University, 2121 Euclid Ave, Cleveland, OH 44115, USA; Biology Teaching and Research Section, Key Laboratory of Tumor Prevention and Treatment of Heilongjiang Province, School of Basic Medical Sciences, Mudanjiang Medical University, Mudanjiang, Heilongjiang Province 157011, China.
Mallorie BoronDepartment of Chemistry, Chemical and Biomedical Engineering and Center for Gene Regulation in Health and Disease (GRHD), Cleveland State University, 2121 Euclid Ave, Cleveland, OH 44115, USA.
Yu ZhaoDepartment of Chemistry, Chemical and Biomedical Engineering and Center for Gene Regulation in Health and Disease (GRHD), Cleveland State University, 2121 Euclid Ave, Cleveland, OH 44115, USA.
Xue-Long SunDepartment of Chemistry, Chemical and Biomedical Engineering and Center for Gene Regulation in Health and Disease (GRHD), Cleveland State University, 2121 Euclid Ave, Cleveland, OH 44115, USA. Electronic address: x.sun55@csuohio.edu.
Cleveland State University · US

Funding

Recombinant and Chemo-/Bio-Orthogonal Synthesis of Liposomal ThrombomodulinR01HL102604 · NHLBI · CLEVELAND STATE UNIVERSITY · PI SUN, XUE-LONG · 2010 to 2013
$1.2M
Synthesis of Biomimetic Proteoglycan and Its Antithrombotic ActivityR15HL138544 · NHLBI · CLEVELAND STATE UNIVERSITY · PI SUN, XUE-LONG · 2017 to 2017
$446k
NHLBI NIH HHS R01 HL102604NHLBI NIH HHS R15 HL138544
6 · The paper itself

Abstract

Thrombomodulin (TM) is an endothelial cell membrane protein that plays essential roles in controlling vascular haemostatic balance. The 4, 5, 6 EGF-like domain of TM (TM

Indexed as

AnticoagulantsAzidesBlood CoagulationClick ChemistryDrug StabilityHumansPolyethylene GlycolsRecombinant ProteinsThrombinThrombomodulinAnticoagulantsAzidesPolyethylene GlycolsRecombinant ProteinsThrombinThrombomodulinCopper-free click chemistryPEGylationProtein CSortase A-mediated ligationThrombin clotting timeThrombomodulin

Identifiers

PMID31513922
PMCPMC6767613
OpenAlexW2972437217

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.