Observational studyAmerican journal of respiratory and critical care medicine2019
The Association between Supraphysiologic Arterial Oxygen Levels and Mortality in Critically Ill Patients. A Multicenter Observational Cohort Study.
Open access · hybridAbstract readMulticenter StudyObservational Study
In one paragraph
Observational study in American journal of respiratory and critical care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 3 pooled it
10.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 3 syntheses or guidelines pooled it, 106 citations in OpenAlex.
- Conservative versus liberal oxygen therapy for mechanically ventilated patients: a systematic review and meta-analysis of randomized controlled trials.Frontiers in medicine · 2026Pooled it
- Monitoring of Brain Tissue Oxygen Tension in Cardiac Arrest: a Translational Systematic Review from Experimental to Clinical Evidence.Neurocritical care · 2024Pooled it
- Higher versus lower fractions of inspired oxygen or targets of arterial oxygenation for adults admitted to the intensive care unit.The Cochrane database of systematic reviews · 2023Pooled it
- Trial
- Automated Oxygen Titration During CPAP and Noninvasive Ventilation in Healthy Subjects With Induced Hypoxemia.Respiratory care · 2023Trial
- Oxygen targets and 6-month outcome after out of hospital cardiac arrest: a pre-planned sub-analysis of the targeted hypothermia versus targeted normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial.Critical care (London, England) · 2022Trial
- Closed-loop oxygen control improves oxygen therapy in acute hypoxemic respiratory failure patients under high flow nasal oxygen: a randomized cross-over study (the HILOOP study).Critical care (London, England) · 2022Trial
- Dysglycaemia and the interaction of chronic and acute glycaemia with mortality post cardiac surgery.Scientific reports · 2025Article
- Differences in Arterial Blood Gas Testing by Race and Sex across 161 U.S. Hospitals in Four Electronic Health Record Databases.American journal of respiratory and critical care medicine · 2025Observational
- Respiratory plasticity induced by chronic hyperoxia in juvenile and adult rats.Respiratory physiology & neurobiology · 2025Article
- Heterogeneity of treatment effect: the case for individualising oxygen therapy in critically ill patients.Critical care (London, England) · 2025Review
- High-velocity nasal insufflation with oxygen assist module versus conventional high-velocity nasal insufflation after extubation: an open-label randomized crossover study.Journal of thoracic disease · 2025Article
- Effect of Oxygen Saturation Targets on Neurologic Outcomes after Cardiac Arrest: A Secondary Analysis of the PILOT Trial.medRxiv : the preprint server for health sciences · 2025Article
- Association Between Early Hyperoxemia Exposure and Intensive Care Unit Mortality in Intracerebral Hemorrhage: An Observational Cohort Analysis.Neurocritical care · 2024Observational
- Oxygen therapy and noninvasive respiratory supports in acute hypoxemic respiratory failure: a narrative review.Annals of intensive care · 2024Review
- Oxygen therapy in acute hypoxemic respiratory failure: guidelines from the SRLF-SFMU consensus conference.Annals of intensive care · 2024Article
- Oxygen thresholds in critically ill patients: need for personalized targets. Author's reply.Intensive care medicine · 2024Article
- Association between arterial oxygen and mortality across critically ill patients with hematologic malignancies: results from an international collaborative network.Intensive care medicine · 2024Article
- Evaluating the clinical and cost-effectiveness of a conservative approach to oxygen therapy for invasively ventilated adults in intensive care: Protocol for the UK-ROX trial.Journal of the Intensive Care Society · 2024Article
- Hyperoxemia and hypoxemia impair cellular oxygenation: a study in healthy volunteers.Intensive care medicine experimental · 2024Article
Corrections and comments
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Authors and funding
18 authors at 11 institutions in 2 countries.
Edward PalmerBloomsbury Institute of Intensive Care Medicine.ORCID 0000-0002-8024-4616
Benjamin PostINFORM-lab, London, United Kingdom.ORCID 0000-0003-0337-0827
Roman KlapaukhResearch Software Development Group, Research IT Services, and.
Giampiero MarraDepartment of Statistical Science, University College London, London, United Kingdom.
Niall S MacCallumBloomsbury Institute of Intensive Care Medicine.
David BrealeyBloomsbury Institute of Intensive Care Medicine.ORCID 0000-0002-1982-3379
Ari ErcoleDivision of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0001-8350-8093
Andrew JonesDepartment of Critical Care, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom.
Simon AshworthDivision of Critical Care, Imperial College Healthcare NHS Trust, London, United Kingdom.ORCID 0000-0001-7927-5784
Peter WatkinsonCritical Care Research Group (Kadoorie Centre), Nuffield Department of Clinical Neurosciences, Medical Sciences Division, University of Oxford, Oxford, United Kingdom.ORCID 0000-0003-1023-3927
Richard BealeDepartment of Critical Care, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom.
Stephen J BrettDepartment of Surgery and Cancer, Imperial College London, London, United Kingdom; and.ORCID 0000-0003-4545-8413
J Duncan YoungCritical Care Research Group (Kadoorie Centre), Nuffield Department of Clinical Neurosciences, Medical Sciences Division, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-6838-4835
Claire BlackINFORM-lab, London, United Kingdom.ORCID 0000-0002-1954-883X
Aasiyah RashanINFORM-lab, London, United Kingdom.
Daniel MartinDivision of Surgery and Interventional Science and.ORCID 0000-0001-6220-8235
Mervyn SingerBloomsbury Institute of Intensive Care Medicine.
Steve HarrisBloomsbury Institute of Intensive Care Medicine.ORCID 0000-0002-4982-1374
Bury College · GBUniversity of Oxford · GBGuy's and St Thomas' NHS Foundation Trust · GBImperial College Healthcare NHS Trust · GBImperial College London · GBKing's College London · GBNational Health Service · GBThe Royal Free Hospital · GBUniversity College London · GBUniversity College London Hospitals NHS Foundation Trust · GBUniversity of Cambridge · GB
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
AgedCritical CareCritical IllnessFemaleHumansIntensive Care UnitsMaleMiddle AgedOxygenOxygen Inhalation TherapyProspective StudiesRisk FactorsOxygencritical carehyperoxialogistic models
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.