ArticleJournal of biomechanical engineering2019
In Situ Joint Stiffness Increases During Skeletal Growth but Decreases Following Partial and Complete Anterior Cruciate Ligament Injury.
Article in Journal of biomechanical engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Estrogen Receptor Expression Changes After Puberty in the Porcine Anterior Cruciate Ligament.bioRxiv : the preprint server for biology · 2026Article
- Age-Related Increases in Graft Tendon Size and Stiffness During Skeletal Growth Enhance Anterior Cruciate Ligament Graft Function and Joint Stability in an Early Adolescent Porcine Model.Journal of biomechanical engineering · 2026Article
- Physeal-sparing anterior cruciate ligament reconstruction in an early adolescent porcine model provides better anterior stability but similar tissue function compared to a juvenile porcine model.Clinical biomechanics (Bristol, Avon) · 2025Article
- Ex vivo robotic measurement of the acute biomechanical impact of anterior cruciate ligament rupture in rats.Journal of biomechanics · 2025Article
- Physeal-sparing anterior cruciate ligament reconstruction provides better initial joint biomechanics than complete transphyseal reconstruction in an early adolescent porcine model.Journal of experimental orthopaedics · 2025Article
- Morphometric analysis of rat and mouse musculoskeletal tissues using high field MRI.Scientific reports · 2025Article
- Neo-Natal Castration Leads to Subtle Differences in Porcine Anterior Cruciate Ligament Morphology and Function in Adolescence.Journal of biomechanical engineering · 2024Article
- Age- and Sex-Specific Joint Biomechanics in Response to Partial and Complete Anterior Cruciate Ligament Injury in the Porcine Model.Journal of athletic training · 2022Article
- Sex-specific biomechanics and morphology of the anterior cruciate ligament during skeletal growth in a porcine model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Age- and sex-specific differences in ACL and ACL bundle size during adolescent growth.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Joint laxity varies in response to partial and complete anterior cruciate ligament injuries throughout skeletal growth.Journal of biomechanics · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Partial and complete anterior cruciate ligament (ACL) injuries occur in both pediatric and adult populations and can result in loss of joint stability and function. The sigmoidal shape of knee joint function (load-translation curve) under applied loads includes a low-load region (described by slack length) followed by a high-load region (described by stiffness). However, the impact of age and injury on these parameters is not fully understood. The current objective was to measure the effects of age and injury on the shape of joint function in a porcine model. In response to an applied anterior-posterior tibial load, in situ slack did not change (p > 0.05), despite sevenfold increases in joint size with increasing age. Joint stiffness increased from an average of 10 N/mm in early youth to 47 N/mm in late adolescence (p < 0.05). In situ ACL stiffness increased similarly, and changes in in situ joint stiffness and ACL stiffness were highly correlated across ages. With complete ACL injury, in situ slack length increased by twofold to fourfold and in situ stiffness decreased threefold to fourfold across ages (p < 0.05). Partial ACL injury resulted in less dramatic, but statistically significant, increases in joint slack and significant decreases in in situ joint stiffness in the adolescent age groups (p < 0.05). This work furthers our understanding of the interaction between joint biomechanics and ACL function throughout growth and the impact of ACL injury in the skeletally immature joint.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.