ArticlePloS one2019
Lack of association between hypothyroxinemia of prematurity and transient thyroid abnormalities with adverse long term neurodevelopmental outcome in very low birth weight infants.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Neurodevelopmental outcomes in children with transient hypothyroxinemia of prematurity assessed using the Denver Developmental Screening Test II (DDST-II).Archives of endocrinology and metabolism · 2026Observational
- A practical gestational age-based algorithm for timely detection of hypothyroidism in premature infants.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Hypothyroxinemia and weight velocity in preterm infants.Journal of pediatric endocrinology & metabolism : JPEM · 2024Article
- Neurodevelopmental Outcome of Infants with Transient Hypothyroxinemia of Prematurity in a Newborn Intensive Care UnitJournal of clinical research in pediatric endocrinology · 2024Article
- Clinical indicators that influence a clinician's decision to start L-thyroxine treatment in prematurity with transient hypothyroxinemia.Italian journal of pediatrics · 2023Article
- An Alternative Route of Treatment in Transient Hypothyroxinemia of Prematurity: Rectal Administration of LevothyroxineJournal of clinical research in pediatric endocrinology · 2023Article
- Postnatal Serum Total Thyroxine Level Associated with Short- and Long-Term Anthropometric Outcomes in Very Preterm Infants.Nutrients · 2022Article
- Transient hypothyroxinemia of prematurity and its risk factors in an extramural neonatal intensive care unit.Archives of endocrinology and metabolism · 2021Article
- The factors associated with transient hypothyroxinemia of prematurity.BMC pediatrics · 2021Article
- Postnatal Serum Total Thyroxine of Very Preterm Infants and Long-Term Neurodevelopmental Outcome.Nutrients · 2021Article
- Hyperoxia Leads to Transient Endocrine Alterations in the Neonatal Rat During Postnatal Development.Frontiers in pediatrics · 2021Article
- Thyroid Function in Preterm/Low Birth Weight Infants: Impact on Diagnosis and Management of Thyroid Dysfunction.Frontiers in endocrinology · 2021Review
- Reference Percentiles and Changes over Time for Total Thyroxine in Preterm Infants: A Retrospective Cohort Study.Diagnostics (Basel, Switzerland) · 2020Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe association between hypothyroxinemia of prematurity with neurodevelopment was controversial.
objectivesTo compare 5 year neurodevelopmental outcomes of very low birth weight (VLBW) infants with hypothyroxinemia of prematurity against those without.
methodsRetrospective cohort study in a single tertiary neonatal centre of VLBW infants born between the year 2008 to 2011. Comparisons were made between all abnormal and normal thyroid function controls using cord thyroid function tests, thyroid function tests during admission and pre-discharge thyroid function test done at term equivalent age. At 2 years corrected age, Bayley scales of infant and toddler development-third edition and Vineland II adaptive behaviour scales (VABS) were collected. At 5 years, Wechsler Preschool and Primary Scale of Intelligence (WPPSI-III), Bracken School Readiness Assessment, VABS and Beery Test of Visual-Motor Integration were collected.
results110 subjects were studied at 2 years corrected age and 80 subjects at 5 years old. 29 infants had abnormal thyroid function test (10 infants with hypothyroxinemia of prematurity and 19 infants with transient thyroid abnormalities). There were no significant difference in the 2 years and 5 years developmental outcome between infants with and without hypothyroxinemia of prematurity (p-value>0.05); and between infants with and without transient thyroid abnormalities (p-value>0.05). There were no significant difference in neurological, visual and hearing impairment between infants with or without hypothyroxinemia of prematurity (p-value>0.05).
conclusionsHypothyroxinemia of prematurity or transient thyroid abnormalities in VLBW infants were not associated with poorer neurodevelopment and did not support the need for levothyroxine supplementation.
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