ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019
The volatile anesthetic sevoflurane reduces neutrophil apoptosis
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Impact of General Anesthetics on Postoperative Infections-A Narrative Review.Life (Basel, Switzerland) · 2025Review
- Sevoflurane, as opposed to pentobarbital anesthesia, attenuates LPS-induced myocardial injury by up-regulating TAF1D.Scientific reports · 2025Article
- Review
- Mesenchymal Stem Cell-Derived Apoptotic Bodies: Biological Functions and Therapeutic Potential.Cells · 2022Review
- Effects of overexpression of Hsp70 in neural stem cells on neurotoxicity and cognitive dysfunction in neonatal mice under sevoflurane exposure.Experimental brain research · 2022Article
- Sevoflurane Offers Neuroprotection in a Cerebral Ischemia/Reperfusion Injury Rat Model Through the E2F1/EZH2/TIMP2 Regulatory Axis.Molecular neurobiology · 2022Article
- αDβ2 as a novel target of experimental polymicrobial sepsis.Frontiers in immunology · 2022Article
- Magnetic resonance imaging under isoflurane anesthesia alters cortical cyclooxygenase-2 expression and glial cell morphology during sepsis-associated neurological dysfunction in rats.Animal models and experimental medicine · 2021Article
- The Microbial Flora in an Experimental Polymicrobial Abdominal Sepsis Model Probed by 16S rRNA Sequencing.Translational perioperative and pain medicine · 2021Article
- The effect of anesthetics on toll like receptor 9.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Volatile Anesthetic Sevoflurane Attenuates Toll-Like Receptor 1/2 Activation.Anesthesia and analgesia · 2020Article
- Sevoflurane, a sigh of relief in COVID-19?British journal of anaesthesia · 2020Article
- Role of β2 Integrins in Neutrophils and Sepsis.Infection and immunity · 2020Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Sepsis remains a significant health care burden, with high morbidities and mortalities. Patients with sepsis often require general anesthesia for procedures and imaging studies. Knowing that anesthetic drugs can pose immunomodulatory effects, it would be critical to understand the impact of anesthetics on sepsis pathophysiology. The volatile anesthetic sevoflurane is a common general anesthetic derived from ether as a prototype. Using a murine sepsis model induced by cecal ligation and puncture surgery, we examined the impact of sevoflurane on sepsis outcome. Different from volatile anesthetic isoflurane, sevoflurane exposure significantly improved the outcome of septic mice. This was associated with less apoptosis in the spleen. Because splenic apoptosis was largely attributed to the apoptosis of neutrophils, we examined the effect of sevoflurane on FasL-induced neutrophil apoptosis. Sevoflurane exposure significantly attenuated apoptosis. Sevoflurane did not affect the binding of FasL to the extracellular domain of Fas receptor. Instead,
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