Evidence map›Paper›PMID 31513075›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2019

Some Aspects of CD8+ T-Cell Exhaustion Are Associated With Altered T-Cell Mitochondrial Features and ROS Content in HIV Infection.

Christian Deo T Deguit, Michelle Hough, Rebecca Hoh, Melissa Krone, Christopher D Pilcher, Jeffrey N Martin, Steven G Deeks, Joseph M McCune, Peter W Hunt, Rachel L Rutishauser

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Immunometabolic Targets in CD8Liver cancer · 2025
    Review
  3. Review
  4. Redox regulation of the immune response.Cellular & molecular immunology · 2022
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Christian Deo T DeguitDepartment of Medicine, University of California, San Francisco, San Francisco, CA.
Michelle HoughDepartment of Medicine, University of California, San Francisco, San Francisco, CA.
Rebecca HohDepartment of Medicine, University of California, San Francisco, San Francisco, CA.
Melissa KroneDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA.
Christopher D PilcherDepartment of Medicine, University of California, San Francisco, San Francisco, CA.
Jeffrey N MartinDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA.
Steven G DeeksDepartment of Medicine, University of California, San Francisco, San Francisco, CA.
Joseph M McCuneDepartment of Medicine, University of California, San Francisco, San Francisco, CA.
Peter W HuntDepartment of Medicine, University of California, San Francisco, San Francisco, CA.
Rachel L RutishauserDepartment of Medicine, University of California, San Francisco, San Francisco, CA.
University of California, San Francisco · USUniversity of the Philippines Manila · PH

Funding

Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Monica Gandhi · 1988 to 2026
$93.6M
Viral reservoirs and sanctuaries in HAART - treated patients: role and mechanismsU19AI096109 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DEEKS, STEVEN GRANT, MCCUNE, JOSEPH M · 2011 to 2015
$29.5M
Training in HIV Translational ResearchT32AI060530 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Diane V Havlir · 2005 to 2026
$6.4M
Determinants of Functional Immune Defects in Treated HIV Infection and AgingR01AI110271 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUNT, PETER W · 2014 to 2018
$3.9M
Host Factors Influencing HIV Viral Load and Infectivity in SemenR01HD074511 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PILCHER, CHRISTOPHER D · 2012 to 2016
$3.1M
Preventing the Establishment of Enfuvirtide-resistance in the Latent ReservoirK24AI069994 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DEEKS, STEVEN GRANT · 2007 to 2016
$1.5M
Dissecting the signals that maintain HIV-specific CD8+ T cell exhaustion - administrative supplementK23AI134327 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RUTISHAUSER, RACHEL LENA · 2018 to 2022
$1.1M
NIAID NIH HHS K23 AI134327NIAID NIH HHS K24 AI069994NIAID NIH HHS P30 AI027763NIAID NIH HHS R01 AI110271NIAID NIH HHS T32 AI060530NIAID NIH HHS U19 AI096109NICHD NIH HHS R01 HD074511
6 · The paper itself

Abstract

backgroundReversing or preventing T-cell exhaustion is an important treatment goal in the context of HIV disease; however, the mechanisms that regulate HIV-specific CD8 T-cell exhaustion are incompletely understood. Since mitochondrial mass (MM), mitochondrial membrane potential (MMP), and cellular reactive oxygen species (ROS) content are altered in exhausted CD8 T cells in other settings, we hypothesized that similar lesions may arise in HIV infection.

methodsWe sampled cryopreserved peripheral blood mononuclear cells from HIV-uninfected (n = 10) and HIV-infected participants with varying levels and mechanisms of viral control: viremic (VL > 2000 copies/mL; n = 8) or aviremic (VL < 40 copies/mL) due to antiretroviral therapy (n = 11) or natural control (n = 9). We characterized the MM, MMP, and ROS content of bulk CD8 T cells and MHC class I tetramer+ HIV-specific CD8 T cells by flow cytometry.

resultsWe observed higher MM, MMP, and ROS content across bulk effector-memory CD8 T-cell subsets in HIV-infected compared with HIV-uninfected participants. Among HIV-specific CD8 T cells, these features did not vary by the extent or mechanism of viral control but were significantly altered in cells displaying characteristics associated with exhaustion (eg, high PD-1 expression, low CD127 expression, and impaired proliferative capacity).

conclusionsWhile we did not find that control of HIV replication in vivo correlates with the CD8 T-cell MM, MMP, or ROS content, we did find that some features of CD8 T-cell exhaustion are associated with alterations in mitochondrial state. Our findings support further studies to probe the relationship between mitochondrial dynamics and CD8 T-cell functionality in HIV infection.

Indexed as

CD8-Positive T-LymphocytesHIV InfectionsHumansInterleukin-7 Receptor alpha SubunitLymphocyte ActivationMembrane Potential, MitochondrialMitochondriaProgrammed Cell Death 1 ReceptorReactive Oxygen SpeciesViremiaInterleukin-7 Receptor alpha SubunitPDCD1 protein, humanProgrammed Cell Death 1 ReceptorReactive Oxygen Species

Identifiers

PMID31513075
PMCPMC6746248
OpenAlexW2972866614

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.