ArticleJournal of veterinary internal medicine2019
Cortisol and adrenocorticotropic hormone concentrations in horses with systemic inflammatory response syndrome.
Article in Journal of veterinary internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Vasopressin stimulation testing in hospitalized foals.Journal of veterinary internal medicine · 2026Article
- Both Season and Equid Type Affect Endogenous Adrenocorticotropic Hormone Concentrations in Healthy Donkeys, Mules and Hinnies in the United States.Animals : an open access journal from MDPI · 2026Article
- Evaluation of systemic inflammatory response syndrome criteria in horses with colic associated with acute gastrointestinal disease.Frontiers in veterinary science · 2026Article
- Equine Pituitary Pars Intermedia Dysfunction.Veterinary sciences · 2025Review
- Association between Eosinophil Count and Cortisol Concentrations in Equids Admitted in the Emergency Unit with Abdominal Pain.Animals : an open access journal from MDPI · 2024Article
- Article
- Stress response as a contributing factor in horses with laminitis.Journal of veterinary science · 2023Article
- Markers for internal neoplasia in the horse.Veterinary medicine and science · 2023Review
- Evaluation of Eosinopenia as a SIRS Biomarker in Critically Ill Horses.Animals : an open access journal from MDPI · 2022Article
- Prospective Case Series of Clinical Signs and Adrenocorticotrophin (ACTH) Concentrations in Seven Horses Transitioning to Pituitary Pars Intermedia Dysfunction (PPID).Veterinary sciences · 2022Article
- Pituitary Pars Intermedia Dysfunction (PPID) in Horses.Veterinary sciences · 2022Review
- Activated platelets and platelet-leukocyte aggregates in the equine systemic inflammatory response syndrome.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2022Article
- Short-Term Effects of Temperature and Thyrotropin-Releasing Hormone Stimulation on Adrenocorticotropin Stability in Horses.Animals : an open access journal from MDPI · 2022Article
- Repeatability of a thyrotropin-releasing hormone stimulation test for diagnosis of pituitary pars intermedia dysfunction in mature horses.Journal of veterinary internal medicine · 2021Article
- Changes Associated with the Peri-Ovulatory Period, Age and Pregnancy in ACTH, Cortisol, Glucose and Insulin Concentrations in Mares.Animals : an open access journal from MDPI · 2021Article
- Article
- Clinical implications of using adrenocorticotropic hormone diagnostic cutoffs or reference intervals to diagnose pituitary pars intermedia dysfunction in mature horses.Journal of veterinary internal medicine · 2021Article
- Effects of administration of ascorbic acid and low-dose hydrocortisone after infusion of sublethal doses of lipopolysaccharide to horses.Journal of veterinary internal medicine · 2020Article
- Cortisol and adrenocorticotropic hormone concentrations in horses with systemic inflammatory response syndrome.Journal of veterinary internal medicine · 2019Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundPlasma adrenocorticotropic hormone (ACTH) and serum cortisol concentrations increase with illness-associated stress. Dynamics of plasma ACTH and serum cortisol concentrations in adult horses with systemic illness are undocumented. HYPOTHESIS/
objectiveTo determine whether ACTH and cortisol concentrations and the ACTH/cortisol ratio vary with survival, the presence of systemic inflammatory response syndrome (SIRS), or ischemic gastrointestinal lesions at admission, or throughout hospitalization. ANIMALS: One hundred fifty-one adult horses.
methodsProspective study measuring serum cortisol and plasma ACTH at admission and on days 2, 4, and 6 of hospitalization. Horses were grouped by outcome (survival, SIRS status, number of SIRS criteria [SIRS score], SIRS severity group, and the presence of an ischemic lesion). Differences between groups and over time for ACTH, cortisol, and ACTH/cortisol ratio were investigated with a mixed effect model. Receiving operator characteristic curves and odds ratios were calculated for survival and ischemia.
resultsIn all groups, ACTH, cortisol, and ACTH/cortisol ratio significantly decreased over time (P < .0001). ACTH, cortisol, and ACTH/cortisol ratio were higher at admission in nonsurvivors, and ACTH and cortisol were higher in horses with ischemic lesions (P < .01). Horses with ACTH above reference interval at admission were 6.10 (2.73-13.68 [95% confidence interval]) times less likely to survive (P < .0001). No significant difference in ACTH, cortisol, and ACTH/cortisol ratio between horses with different SIRS status, scores, or groups were detected, although nonsurvivors had a higher SIRS score (P < .0001). CONCLUSIONS AND CLINICAL IMPORTANCE: Pituitary and adrenal responses are altered in nonsurviving horses and those with an ischemic gastrointestinal lesion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.