ArticleJournal of anatomy2020
Quantification of the regional bioarchitecture in the human aorta.
Article in Journal of anatomy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 45 citations in OpenAlex.
- Computational multiscale analysis of growth and remodeling in the ascending aorta of the Marfan mouse.Biomechanics and modeling in mechanobiology · 2026Article
- Bulk density-calibrated fiber networks reveal local weakness as the driver of protease-dependent aortic failure.International journal of engineering science · 2026Article
- Analysis of Energy Dissipation Ratio in Commercial Bovine Pericardial Patches Treated with Glutaraldehyde Solution.Journal of functional biomaterials · 2026Article
- Geometric and mechanical changes along the length of the porcine aorta.Journal of biomechanics · 2026Article
- Neuroimmune Dynamics in Diseases of the Arterial Wall: Mechanistic Foundations and Translational Prospects.Current atherosclerosis reports · 2026Review
- Orientation-based evaluation of scleral collagen fibers in uveitic secondary glaucoma.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Biomechanical Variation of the Vessel Wall Along the Length of the Healthy Aorta-Linking Geometric, Flow-, and Pressure-Mediated Adaptations.Journal of biomechanical engineering · 2026Review
- Geometric Aging of the Thoracic Aorta: Insights From 2 Large Cohorts.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Wall Tensile Stress Maps of Human Aneurysmal Aorta Demonstrate a High Biaxiality Ratio Corresponds with Wall Tissue Microstructure and Local Oxidative Stress Response Distinctly for Bicuspid and Tricuspid Aortic Valve Patients.Annals of biomedical engineering · 2025Article
- Morphological changes in polyester prosthesis geometry after open aortic repair.BMC cardiovascular disorders · 2025Article
- Calciprotein particles induce arterial stiffening ex vivo and impair vascular cell function.Communications biology · 2024Article
- On the Importance of Including Cohesive Zone Models in Modelling Mixed-Mode Aneurysm Rupture.Cardiovascular engineering and technology · 2024Article
- Unravelling the impact of active and passive contributors to arterial stiffness in male mice and their role in vascular aging.Scientific reports · 2024Article
- An Eye into the Aorta: The Role of Extracellular Matrix Regulatory GenesInternational journal of molecular sciences · 2024Review
- Variability in structure, morphology, and mechanical properties of the descending thoracic and infrarenal aorta around their circumference.Journal of the mechanical behavior of biomedical materials · 2024Article
- Renal denervation restores biomechanics of carotid arteries in a rat model of hypertension.Scientific reports · 2024Article
- Biomechanical effects of hemin and sildenafil treatments on the aortic wall of chronic-hypoxic lambs.Frontiers in bioengineering and biotechnology · 2024Article
- Association of NOTCH3 With Elastic Fiber Dispersion in the Infrarenal Abdominal Aorta of Cynomolgus Monkeys.Arteriosclerosis, thrombosis, and vascular biology · 2023Article
- Article
- The non-affine fiber network solver: A multiscale fiber network material model for finite-element analysis.Journal of the mechanical behavior of biomedical materials · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regional variance in human aortic bioarchitecture responsible for the elasticity of the vessel is poorly understood. The current study quantifies the elements responsible for aortic compliance, namely, elastin, collagen and smooth muscle cells, using histological and stereological techniques on human tissue with a focus on regional heterogeneity. Using donated cadaveric tissue, a series of samples were excised between the proximal ascending aorta and the distal abdominal aorta, for five cadavers, each of which underwent various staining procedures to enhance specific constituents of the wall. Using polarised light microscopy techniques, the orientation of collagen fibres was studied for each location and each tunical layer of the aorta. Significant transmural and longitudinal heterogeneity in collagen fibre orientations were uncovered throughout the vessel. It is shown that a von Mises mixture model is required accurately to fit the complex collagen fibre distributions that exist along the aorta. Additionally, collagen and smooth muscle cell density was observed to increase with increasing distance from the heart, whereas elastin density decreased. Evidence clearly demonstrates that the aorta is a highly heterogeneous vessel which cannot be simplistically represented by a single compliance value. The quantification and fitting of the regional aortic bioarchitectural data, although not without its limitations, including mean cohort age of 77.6 years, facilitates the development of next-generation finite element models that can potentially simulate the influence of regional aortic composition and microstructure on vessel biomechanics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.